Nature Headline! China’s CAR-T Therapy Breakthrough Leads the World—A New Hope for Autoimmune Disease Treatment  

🌟 **Nature Headline!** China’s CAR-T Therapy Breakthrough Leads the World—A New Hope for Autoimmune Disease Treatment

Autoimmune

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💪 Chinese medical scientists have made a major breakthrough in treating autoimmune diseases with revolutionary CAR-T therapy. This study, conducted by scientists from three Chinese universities, was published in the prestigious journal *Cell* on October 04, 2024. It is the first study to use universal CAR-T cells derived from healthy donors, successfully helping three autoimmune disease patients achieve long-term remission. This marks a new era in treating difficult-to-treat autoimmune diseases globally.

📈 Traditional CAR-T therapies are primarily used to treat cancer, relying on extracting immune cells from patients, modifying them genetically, and reinfusing them—an expensive and complex process. However, the Chinese research team developed a next-generation CAR-T therapy that uses gene-editing technology to modify donor-derived T cells. These cells can be mass-produced and are ready for immediate use. This new approach not only significantly reduces treatment costs but also shortens the preparation time.

In this study, three patients with severe autoimmune diseases received the universal CAR-T therapy, including a 57-year-old male patient, Mr. Gong, who suffered from systemic sclerosis. Just three days after treatment, his skin showed noticeable improvement, and he regained movement in his fingers. Two weeks later, he returned to work. Now, over a year of follow-up later, Mr. Gong’s condition remains stable, and he says he “feels great.” This demonstrates the therapy’s potential for long-term effectiveness and safety.

The development of this next-generation CAR-T therapy uses CRISPR-Cas9 gene-editing technology, allowing the modified cells to target and eliminate B cells—critical players in various autoimmune diseases. After treatment, the diseased B cells disappeared from patients, and healthy B cells regenerated, all without the occurrence of common severe side effects like cytokine release syndrome.

This achievement not only brings new hope for autoimmune disease treatment but also paves the way for future applications of CAR-T cell therapy. As clinical trials continue, more patients are expected to benefit from this groundbreaking treatment.

🎉🎉To assess whether the condition is suitable for clinic therapy, you can submit Advanced Medicine in China for preliminary evaluation!

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