Hematological Neoplasms

On February 8, 2023, JCO Online published the clinical results from the US Lymphoma CAR-T Alliance on Brexucabtagene Autoleucel (Tecartus, brexu-cel) as a standard treatment for relapsed/refractory mantle cell lymphoma. Let’s take a look with the editor.

Currently, CAR-T cell therapy is applicable to the treatment of B-NHL and relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL) in children and adults.

Currently, there is no clearly defined standard of care (SOC) for patients with relapsed/refractory follicular lymphoma (R/R FL).

Kymriah (Tisagenlecleucel) is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy that has shown clinically meaningful results in patients with relapsed/refractory B-cell lymphoma.

On March 18, 2024, at Ruijin Hospital in Shanghai, China, the 100th patient with relapsed/refractory lymphoma achieved complete remission after CAR-T cell therapy and was discharged.

Promising News from Cellular Therapy. On March 29, 2024, Ms. Mo (alias), a patient with diffuse large B-cell lymphoma who received CAR-T cell therapy, was discharged from the Department of Hematology and Rheumatology at the People’s Hospital of Zhuhai.

Can a single injection eliminate cancer cells? If it weren’t for her own personal experience, Ms. Zhou, who had been tormented by relapsed/refractory diffuse large B-cell lymphoma (DLBCL) for a long time, would hardly believe it.

Breyanzi is developed and produced by the global biopharmaceutical company manufacturer is Bristol Myers Squibb (BMS).

Breyanzi (lisocabtagene maraleucel; liso-cel) is a CD19-targeted CAR-T cell therapy with a 4-1BB costimulatory domain, which enhances the expansion and persistence of CAR-T cells.

On May 15th, 2024 (local time), the U.S. Food and Drug Administration (FDA) announced the accelerated approval of Breyanzi (lisocabtagene maraleucel), Bristol Myers Squibb’s CAR-T therapy, for an expanded indication to treat adult patients with relapsed or refractory follicular lymphoma (FL) who have received at least two prior systemic therapies.

According to a retrospective study presented at the 2024 Transplantation & Cellular Therapy Meetings, a single infusion of brexucabtagene autoleucel (brexu-cel) achieved a higher rate of central nervous system (CNS) remission in patients with relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL) and active CNS involvement.

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