TIL therapy is approved by the U.S. Food and Drug Administration for patients with advanced melanoma. At UChicago Medicine, we are also testing TIL therapy in a clinical trial for patients with cervical cancer. Our physician-researchers also plan to study this treatment for other types of solid tumors in future clinical trials.
TIL therapy
TIL therapy involves several steps before you can receive your new TILs: You will meet with your medical oncologist, who will explain the risks and benefits of TIL therapy. Together, you will decide if this treatment is right for you. If you are a candidate for TIL therapy, your surgeon will remove a portion of Read More
After you’ve completed your conditioning chemotherapy, you are ready for your TIL therapy. You will receive your treatment in a specialized cellular therapy unit in the Center for Care and Discovery that is staffed by physicians and nurses who are experts in cellular therapy care. Here’s what you can expect: We will place a temporary central venous catheter (central Read More
After TIL therapy: You will return to the clinic to see your medical oncologist once or twice a week for the first month. During these follow-up visits, we will monitor your blood counts and check for complications. If your blood counts are low, we will give you a transfusion. Three months after your TIL therapy, Read More
TIL therapy is an intense treatment with some short-term risks from conditioning chemotherapy. These include: Low blood counts that may require blood transfusions Infections Fatigue Nausea and vomiting Diarrhea Hair loss Mouth sores IL-2, which is used to stimulate your TILs, can also cause temporary side effects, including: Fever Rash Low blood pressure Abnormal heart Read More
You may have some temporary pain or discomfort during certain portions of your TIL therapy. For example, you may have some pain for a few days after your surgery to remove your tumor. You may also find the central line (central venous catheter) uncomfortable during the week you have your infusion. The TIL infusion itself Read More
During your conditioning chemotherapy and for a few weeks after your TIL therapy, you should take some common-sense precautions to avoid infections. For example, you should wash your hands frequently and avoid exposure to young children, if possible. You do not need to isolate yourself at home.
CAR T-cell therapy is another innovative cell therapy offered at UChicago Medicine. Like TIL therapy, CAR (chimeric antigen receptor) T-cell therapy uses your body’s immune cells to fight cancer. However, CAR T-cell therapy uses T cells from your blood, not from your tumor. Then, new T cells re-engineered in a laboratory to seek out a Read More