China’s Fully Human BCMA CAR-T Therapy: Bringing New Hope for High-Risk Relapsed/Refractory Multiple Myeloma

China’s Fully Human BCMA CAR-T Therapy: Bringing New Hope for High-Risk Relapsed/Refractory Multiple Myeloma

Mutiple Myeloma

Multiple Myeloma (MM) is a complex and aggressive cancer originating from plasma cells, posing significant treatment challenges due to its resistance to therapy. For patients with high-risk MM, especially those who experience relapse after multiple lines of treatment, finding an effective therapy is critical. Recently, Chinese medical team successfully treated a case of high-risk relapsed/refractory MM (RRMM) using fully human BCMA CAR-T cell therapy, offering new hope for such difficult cases.

**Case Overview**

The patient, a 56-year-old woman, presented with anemia during a routine check-up and was later diagnosed with MM. Despite undergoing several treatment regimens, including VRd (bortezomib, lenalidomide, dexamethasone) and Dara-DECP followed by autologous stem cell transplantation (ASCT), the disease continued to progress, with extramedullary disease (EMD) manifestations complicating the case.

**Challenges and Treatment Journey**

After initial treatments failed to achieve long-term remission, the patient’s condition worsened, with new lesions detected in the pancreas and multiple subcutaneous nodules indicating possible metastasis. Given the aggressive nature of the disease and the presence of EMD, which is associated with a poor prognosis, the medical team opted for a BCMA-targeted CAR-T cell therapy using Iquarense (Ikaros CAR-T), the first CAR-T product approved for MM treatment in China.

**CAR-T Therapy and Results**

Following pre-conditioning with a fludarabine-cyclophosphamide (FC) regimen, the patient received the BCMA CAR-T therapy. The treatment was well-tolerated, with only mild cytokine release syndrome (CRS) observed. Remarkably, within three months post-treatment, PET-CT scans showed no signs of active disease, and the patient achieved a complete response (CR), which has been sustained for eight months.

**Significance and Future Implications**

This case highlights the potential of BCMA CAR-T therapy as a powerful option for patients with high-risk, relapsed/refractory MM, particularly those with EMD. The successful outcome not only provides new hope for patients facing similar challenges but also contributes valuable insights for future treatment strategies. Iquarense, with its low immunogenicity and prolonged persistence in the body, represents a promising advance in the fight against this formidable disease.

For patients with high-risk MM, it is crucial to consider genetic factors, treatment response, and overall disease dynamics when selecting a therapeutic approach. As this case demonstrates, BCMA CAR-T therapy offers a viable path forward, particularly for those with limited options due to disease progression or EMD.

To assess whether the condition is suitable for CAR-T or clinic therapy, you can submit Advanced Medicine in China for preliminary evaluation!

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