In the medical field, unresectable advanced or metastatic gastric or gastroesophageal junction (#GEJ) adenocarcinoma has always been a daunting challenge. However, the latest research brings new hope to this field. #metastaticgastric #gastroesophagealjunction

**Innovative Treatment Brings New Hope**

The latest study published in *Nature Medicine* indicates that the drug Cadonilimab, in combination with chemotherapy, has significant efficacy and safety for patients with HER2-negative unresectable advanced or metastatic gastric or GEJ adenocarcinoma. This study, jointly conducted by scholars such as Jiafu Ji, Ziyu Li, and Lin Shen from Peking University, brings exciting news to this field.

**Key Findings**

Key findings of the study include:

– Cadonilimab in combination with chemotherapy has significant benefits for tumor response and survival, offering patients a ray of hope.

– The median overall survival reached 17.48 months in all patients, with higher benefits observed in patients with higher PD-L1 expression, reaching a median overall survival of 20.32 months in patients with PD-L1 CPS≥5.

– Even in patients with PD-L1 CPS<1, encouraging survival benefits were observed, with a median overall survival of 17.64 months.

– The drug demonstrated good safety profile, with treatment-related adverse events being manageable and tolerable.

**Dawning of Hope**

This study brings new hope to patients with gastric adenocarcinoma or GEJ adenocarcinoma. Regardless of PD-L1 expression, Cadonilimab in combination with chemotherapy exhibits encouraging clinical activity and manageable safety. This innovative treatment regimen holds the promise of fundamentally changing this life-threatening disease worldwide.

**Conclusion**

This groundbreaking research highlights the leading position of Chinese medical teams in the field of gastric adenocarcinoma treatment. With further research, we hope to see more innovative treatment options emerge, providing patients with more opportunities for survival and better quality of life. Let us look forward to the progress of medical science and bring more hope for health!

Want to know more Advanced medicine in China, You can send electronic copies or photos of genetic testing reports and diagnostic reports to the email address: doctor.huang@globecancer.com

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