Exceptional Efficacy of CAR-T Therapy in China: Disease Control Rate for Advanced Liver Cancer Reaches 78% to 91.3%

### Exceptional Efficacy of CAR-T Therapy in China: Disease Control Rate for Advanced Liver Cancer Reaches 78% to 91.3%

Liver Cancer

#CARTTherapy #LiverCancer #SolidTumors

In recent years, China has made remarkable advances in CAR-T cell therapy, particularly demonstrating exceptional potential in liver cancer treatment. CAR-T cell therapy, or chimeric antigen receptor T-cell therapy, involves genetically engineering a patient’s T-cells to enable precise recognition and elimination of cancer cells. This innovative therapy has shown impressive outcomes in treating hematologic cancers and is now showing promising potential in fighting more complex solid tumors—especially liver cancer.

### **A Ray of Hope with CAR-T Therapy Amid High Incidence of Liver Cancer**

Liver cancer ranks among the top three cancers worldwide and poses a significant health threat. The high incidence of liver cancer, largely related to chronic hepatitis B infection, is particularly evident in China, which accounts for 42.4% of global liver cancer cases, with an annual increase of 368,000 new cases. For many liver cancer patients, especially those with advanced-stage disease, traditional treatments offer limited effectiveness. CAR-T therapy, however, provides new hope. Recent studies indicate that the disease control rate of CAR-T therapy for advanced liver cancer patients in China has reached an impressive 78% to 91.3%, showcasing its powerful treatment potential.

### **Patient Stories: CAR-T Therapy as a Turning Point in Life**

One inspiring case is that of Mr. Zhang from China. Long troubled by chronic hepatitis, he was diagnosed with advanced liver cancer in 2016. Despite undergoing liver resection, the cancer recurred with multiple intrahepatic metastases, spreading to retroperitoneal lymph nodes and forming a tumor thrombus in the inferior vena cava. After multiple rounds of embolization and ablation, the tumor remained uncontrolled. Given the limited efficacy of traditional treatments, doctors recommended CAR-T therapy. Following CAR-T treatment, Mr. Zhang’s tumors completely disappeared, and he has remained tumor-free for over seven years without severe side effects. This case highlights both the efficacy of CAR-T therapy and its potential to offer hope.

Another patient, Mr. Li, also benefitted from CAR-T therapy. When other treatments proved ineffective, doctors developed a liver cancer-specific CAR-T “special force” of four billion cells for him. Upon injection of these modified CAR-T cells, Mr. Li’s alpha-fetoprotein levels dropped rapidly, and the tumor gradually shrank. In subsequent treatments, Mr. Li’s tumor disappeared entirely, and his condition has remained stable long-term. This success story further underscores CAR-T therapy’s impressive results in treating liver cancer.

### **Future Outlook: Challenges and Opportunities for CAR-T Therapy in China**

While CAR-T therapy has achieved notable successes, challenges remain. Compared to hematologic cancers, the environment for treating solid tumors is more complex, and enhancing the efficacy of CAR-T cells in solid tumors requires ongoing optimization. However, the promising research and clinical results instill confidence in CAR-T therapy’s future in liver cancer treatment. Chinese researchers are actively working to refine CAR-T cell therapy, explore combination treatment strategies, and foster international collaboration to benefit more patients.

In the future, CAR-T therapy in China is expected to become a powerful tool in liver cancer treatment, offering new hope to thousands of patients. With ongoing technological advancements and deepening clinical practice, CAR-T therapy in China will continue to advance cancer immunotherapy and provide new possibilities for the health of liver cancer patients.

🎉🎉To assess whether the condition is suitable for CAR-T therapy, you can submit pathology reports, treatment history, and discharge summaries to the Medical Department of <Advanced Medicine in China> for preliminary evaluation!

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Email: doctor.huang@globecancer.com

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