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10 months ago CAR-T

The Chinese CAR-T therapy achieves a miraculous cure for advanced liver cancer, creating wonders in the field of cellular treatment for solid tumors.

The Chinese CAR-T therapy achieves a miraculous cure for advanced liver cancer, creating wonders in the field of cellular treatment for solid tumors.🌞🌞

🥰Surviving Against the Odds: A Chinese Doctor’s Journey with Liver Tumor🥰

Zou began his career in 1989 and has dedicated 30 years as an obstetrician-gynecologist, tirelessly working on the frontline of clinical care.

⭐️”One afternoon, I felt excruciating pain in my right shoulder while sitting in the office. It turned out I had three massive tumors on my liver. At that moment, I had no idea that my life had entered a countdown,” recalls Dr. Zou.⭐️

⭐️”Dr. Zou is in the advanced stage of liver cancer, with metastasis to the lungs,” urgently declared Prof.Shi as he convened a team of experts to consult on Dr. Zou’s condition.⭐️

⭐️ “With conventional treatment, the survival period is typically 3-6 months. Even with surgery, there’s no hope,” stated Prof.Shi.⭐️ Dr. Zou, a doctor himself, continued to ponder work matters, but colleagues and loved ones were tirelessly searching for any possible cure.

⭐️”Prof.Shi mentioned this immunotherapy, an antibody treatment,” said Dr. Zou’s wife.⭐️

Antibody therapy, specifically Chimeric Antigen Receptor T-cell Immunotherapy (CAR-T), is a novel precision-targeted treatment for tumors. Using genetic engineering, T-cells are activated and equipped with a guided navigation device called CAR (Chimeric Antigen Receptor), transforming ordinary warriors into super soldiers known as CAR-T cells. These cells specifically recognize and efficiently eliminate tumor cells, achieving the goal of treating malignant tumors.

Fortunately, Dr. Zou’s health indicators perfectly matched the criteria for CAR-T therapy, providing him with a chance to defy death.

⭐️”In the early stages, I needed treatment every two weeks. Finally, after five or six sessions, my cancer cells started degenerating and liquefying. By now, the last and originally largest tumor has significantly liquefied and been absorbed,” Dr. Zou said.⭐️

⭐️”A miracle happened. We have taken a significant step in overcoming liver cancer in humans,” Prof.Shi added.⭐️

As the treatment gradually took effect, Dr. Zou’s health improved, allowing him to resume his daily work. After completing the treatment cycle, Dr. Zou once again donned the white coat, transitioning from patient to doctor.

In his heart, a stronger belief in the sincerity towards the medical profession and the health of patients emerged.

#SurvivorStories #MedicalMiracle #Inspiration #CancerSurvivor #CARTTherapy #AgainstAllOdds #HealthJourney #BelieveInMiracles #advancedmedicineinchina #chinesemedicine

10 months ago CAR-T

🥰Chinese CAR-T Therapy: A Beacon of Hope for Lymphoma Patients🥰

🌞In a groundbreaking development, the Hematology Department at Peking Union Medical College Hospital has achieved remarkable treatment outcomes with commercial CAR-T therapy since 2021.

🌞Meet Mr. Li, a 59-year-old with a history of hypertension. In September 2019, he noticed swelling in his right elbow, which worsened over three months, prompting concerns. After visits to multiple hospitals, he was diagnosed with Diffuse Large B-Cell Lymphoma (DLBCL). Further consultations revealed additional challenges: the presence of TP53 and MYD88 gene mutations, adding complexity to his case.

🌞Local hospitals initiated frontline treatments, utilizing drugs such as cyclophosphamide, prednisone, ibrutinib, and rituximab. While the initial treatment provided relief, it was short-lived. After six months of rest, Mr. Li experienced discomfort in his lower abdomen, leading to a subsequent diagnosis of DLBCL metastasis. Despite second, third, and fourth-line treatments at local hospitals, his condition remained uncontrolled.

🌞In December 2021, Mr. Li placed his last hope in the hands of the lymphoma team at Peking Union Medical College Hospital and underwent CAR-T therapy.

On December 27, 2021, the patient underwent a successful single-cell collection, followed by CAR-T cell infusion on January 20, 2022. Post-infusion, all indicators returned to normal, with only transient fever and CAR-T-related neutropenia observed. Targeted treatment promptly addressed these symptoms, leading to their resolution. One month after discharge, a complete response (CR) was achieved upon evaluation.

🌞Professor Wang Wei, drawing on clinical expertise, emphasized that:

TP53-mutated patients often exhibit limited response to conventional frontline treatments, making CAR-T therapy a potential benefit.

🌞For high-risk patients, especially those with dual expression and recurrence within 12 months, CAR-T therapy as a second-line treatment may yield benefits.

Post-CAR-T hematopoietic suppression, while common, requires nuanced management based on various factors. R-CHOP shows safety and efficacy in R/R DLBCL. Post-CAR-T bone marrow suppression is influenced by factors like prior chemotherapy lines, occurrence of CRS/ICANs, necessitating comprehensive clinical assessment and supportive care.

🌞In summary, CAR-T therapy presents a promising avenue for patients facing challenging lymphoma scenarios. The successful case of Mr. Li underscores the potential efficacy and safety of this innovative treatment at Peking Union Medical College Hospital.

#CART #Success #LymphomaTreatment #MedicalAdvancements #pekingunion #Chinesecart

10 months ago CAR-T

Beacon of Hope in Cancer Treatment – What is the treatment process for CAR-T cell therapy?

Beacon of Hope in Cancer Treatment

😊😊😊 What is the treatment process for CAR-T cell therapy?

CAR-T cell therapy has emerged as a global miracle in cancer treatment, capturing widespread attention. By loading CAR onto T cells, these “super soldiers” can specifically identify and efficiently eliminate tumor cells, offering a fresh perspective for cancer patients.

Treatment Procedure:

💙Assessment: Doctors first evaluate whether the patient is suitable for CAR-T therapy, ensuring maximum benefit.

❤️Isolation and Sampling: T cells are extracted from peripheral blood, preparing for subsequent modifications.

💛Cell Modification: T cells are activated and modified in vitro, using biotechnological techniques to load the CAR structure for specific tumor cell recognition.

🧡Ex Vivo Expansion: Depending on the patient’s weight and treatment period, CAR-T cells are significantly expanded ex vivo to ensure an adequate quantity for treatment.

💚Infusion into the Body: The expanded CAR-T cells are reintroduced into the patient’s body, allowing the “super soldiers” to combat tumors.

💜Subsequent Monitoring: Close monitoring of the treatment’s effectiveness post CAR-T cell infusion, promptly addressing any adverse reactions to ensure optimal patient outcomes.

The advent of CAR-T cell therapy brings a new dawn for cancer patients, with its unique treatment mechanism and remarkable effects positioning it as a leader in the field of cancer immunotherapy. This scientific marvel is spreading hope globally, opening a gateway to recovery for cancer patients.

#CARTCellTherapy #CancerTreatment #HopeInScience #CART #Cancer #Whatiscancer #cancerpatient

10 months ago CAR-T

A Miraculous Journey: Israeli Artist Finds Cure for Multiple Myeloma in Hangzhou China

A Miraculous Journey: Israeli Artist Finds Cure for Multiple Myeloma in Hangzhou China

In a remarkable medical story, we turn our attention to the experiences of a friend seeking treatment in Hangzhou China. Tali, a well-known artist from Israel. In 2012, she was diagnosed with multiple myeloma, a malignant blood disease, and after seeking treatment in various European countries, including Israel and France, she found no definitive cure. In a moment of despair, she discovered a solution from Hangzhou, China, through the European Bone Marrow Transplant Association.

On October 6th, Tali and her family boarded a flight from Israel to Hangzhou. Under the meticulous care of Professor Huang He and his team at Zhejiang University’s First Hospital, Tali underwent over a month of intensive treatment. Today, Tali is finally on the road to recovery, expressing her gratitude to the medical staff through her preferred medium – art.

In the hospital room, Tali and Professor Huang He share laughs and conversations. The weather looks promising, initially being skeptical about her health when arriving in Hangzhou, encouragement from the medical team reignited her hope for recovery. Using her artistic language, she documented every moment of the treatment process.

After undergoing treatment, the excruciating bone pain gradually lessened, indicating a positive turn in her health.

“I can feel my body improving bit by bit. Green cells are gradually replacing the red ones, and my bone pain has completely disappeared. There are no tumor cells in the bone marrow anymore – they have vanished entirely.” Tali expressed.

The advanced treatment utilized at Zhejiang University’s First Hospital involves cutting-edge blood cell separation technology. Lymphocytes are extracted and genetically engineered to attack malignant tumor cells, successfully curing multiple myeloma. This revolutionary technique is known as CAR-T cell therapy. Zhejiang University’s First Hospital stands out as one of the earliest and most experienced clinical research centers using this technology, making it a pioneer in the field.

In here we bring you this inspiring story from Hangzhou, where art, science, and the human spirit come together in a tale of triumph over adversity.

#HangzhouMedicalMiracle #CARTCellTherapy #InspiringStories #MedicalAdvancements

11 months ago CAR-T

Breakthrough CAR-T Cell Therapy for R/R B-Cell ALL: A Game-Changer in Chinese Medical Innovation

Breakthrough CAR-T Cell Therapy for R/R B-Cell ALL: A Game-Changer in Chinese Medical Innovation

ALL- Acute Lymphoblastic Leukemia

The Fourth China Hematology Development Conference – CAR-T Frontier Forum and the First CAR-T Cell Immunotherapy Summit (JCIS), held on January 5, 2024, in Tianjin.

Potential Best-in-Class: Inaticabtagene Autoleucel Redefining Long-term Outcomes for R/R B-ALL

Professor Ma Jun from the Harbin Institute of Hematology and Oncology shared notable progress in immunotherapy and cell treatment for Chinese ALL. Previously, the overall complete response (CR) rate for adult R/R ALL treatment in China was approximately 40%, with a mere 11% 3-year survival rate. The introduction of CAR-T cell therapy has been a paradigm shift, altering the long-term outcomes for R/R B-ALL patients.

Inaticabtagene Autoleucel demonstrates superior efficacy:

Higher overall response rates (ORR) at 3 months and beyond, with median duration of response (DOR) and overall survival (OS) surpassing other products.

Patients treated with Inaticabtagene Autoleucel exhibit similar long-term benefits in OS, whether or not they undergo subsequent transplantation.

Inaticabtagene Autoleucel boasts enhanced safety:

Lower incidence rates of grade 3 cytokine release syndrome (CRS), grade 3 immune effector cell-associated neurotoxicity syndrome (ICANS), and infusion-related mortality compared to other CAR-T products.

Moreover, in minimal residual disease-positive (MRD+) B-ALL patients, CAR-T cell therapy has shown significant progress. It eradicates MRD, improves survival rates, and may serve as a first-line consolidation therapy for CR patients, aiding in:

Higher remission rates

Reduced transplant requirements, mitigating transplant-related complications

Maintenance of long-term remission for those unsuitable for allo-HSCT or unwilling to undergo it

Improved overall survival

Lower intensity and duration of intensive chemotherapy, leading to shorter treatment times and enhanced compliance.

The Future Outlook: Believing in the potential of CAR-T cell therapy, it is anticipated that this innovative treatment will extend hope to currently incurable diseases such as solid tumors and brain tumors. The strides made in Chinese medical innovation, exemplified by Inaticabtagene Autoleucel, signal a promising future for the global landscape of CAR-T cell therapy.

#CARTRevolution #InaticabtageneAutoleucel #HematologicCancerTherapy #ClinicalBreakthrough #ChinaHematologyConference #JCIS #BAllTreatment #MedicalAdvancements #CancerResearch #TreatmentInnovation #InaticabtageneAutoleucel #Autoleucel #ChineseCART #CARTTherapy #cancer #Bloodcancer #MedicineinCHINA #Medicaltourismo #Advancedmedicine #cancertherapy #leukemia

11 months ago CAR-T

Clinical Breakthrough: Chinese CAR-T – Inaticabtagene Autoleucel Revolutionizing Hematologic Cancer Therapy

“Clinical Breakthrough: Chinese CAR-T – Inaticabtagene Autoleucel Revolutionizing Hematologic Cancer Therapy”

On January 5, 2024, the Fourth Chinese Hematology Development Conference was convened in Tianjin, China, concurrently hosting the CAR-T Frontier Forum and the First CAR-T Cell Immunotherapy Summit (JCIS). The focus was directed towards the latest advancements and clinical applications of Inaticabtagene Autoleucel, presenting new pathways for standardized treatments.

Under the moderation of Professors Wu Depei and Hu Yu, Professor Wang Ying from the Institute of Hematology at the Chinese Academy of Medical Sciences presented a specialized lecture titled “Interpreting Key Clinical Data of Inaticabtagene Autoleucel.” Professor Wang highlighted the challenges faced by adult B-ALL patients in China, commonly treated with salvage chemotherapy ± hematopoietic stem cell transplantation. However, the median survival period is only 2-6 months, and targeted therapies yield a median survival of merely 7.7 months, necessitating an urgent need for more effective treatment methods. Recently, the Inaticabtagene Autoleucel infusion has been approved for treating adult R/R B-ALL patients.

Critical clinical research (NCT04684147) has revealed the substantial outcomes achieved with a single treatment of Inaticabtagene Autoleucel:

Rapid and profound remission: Within 3 months of treatment, the overall response rate (ORR) reached an impressive 82.1%, with a 100% negativity rate for minimal residual disease (MRD), showcasing the remarkable effects of Inaticabtagene Autoleucel within a short span.

Enduring remission: The 3-month post-treatment overall remission rate stood at 64.1%, with a 12-month sustained remission rate (DOR) of 80%. With a median follow-up of 8.0 months, the median relapse-free survival (RFS) period has not been reached. The one-year survival rates for overall infused patients, those achieving complete response (CR)/complete response with incomplete hematological recovery (CRi) within 3 months, and those reaching CR/CRi at 3 months were 67.9%, 72.0%, and 85.6%, respectively.

Good safety profile: The incidence rate of ≥3-grade cytokine release syndrome (CRS) was only 10.3%, and that of ≥3-grade immune effector cell-associated neurotoxicity syndrome (ICANS) was merely 7.7%. Moreover, patients recovered post-treatment without complications.

Furthermore, data from over 100 patients validated the clinical efficacy and safety of Inaticabtagene Autoleucel, affirming its robustness and offering renewed hope to a larger patient population. This breakthrough treatment provides a new avenue for tackling challenging diseases and is poised to revolutionize the landscape of hematologic cancer therapy.

11 months ago CAR-T

Exploring Tumor Vitality: Chinese CAR-T Therapy Grants Patients Complete Remission

Exploring Tumor Vitality: Chinese CAR-T Therapy Grants Patients Complete Remission

“Is it true? It’s so unbelievable!” said Chen, the “fortunate one.”

On June 22, 2021, the approval of China’s first CAR-T cell therapy product, Yescarta, marked a significant milestone in medicine. Behind this milestone lies the story of a patient named Chen, diagnosed with diffuse large B-cell lymphoma, which not only brought confidence to patients but also injected fresh belief into medical professionals.

Chen was diagnosed with diffuse large B-cell lymphoma in July 2019, underwent primary treatment, only to unfortunately relapse. Due to the insufficient efficacy of secondary treatment and considering the TP53 mutation, conventional treatment plans were inadequate. However, the approval of Yescarta on June 22, 2021, brought a glimmer of hope for patients. Under the meticulous planning of the expert team in the Hematology Department of Ruijin Hospital, Chen successfully underwent CAR-T cell infusion therapy on August 2.

One year after the evaluation of the treatment’s effectiveness, Chen’s condition still maintains complete remission. This achievement has brought immense hope and joy to patients with diffuse large B-cell lymphoma, strengthening the belief in the potential of CAR-T therapy among medical practitioners.

“This is not only good news for patients but also an encouragement and boost to us, clinical doctors in the field of hematology,” stated Professor Xu Pengpeng.

This case represents not only a medical breakthrough but also serves as an inspiration for individuals battling diffuse large B-cell lymphoma. The success of CAR-T therapy reveals new possibilities, offering a new pathway to break the limitations of the “mere six-month survival period” in cancer treatment. May more patients benefit from this breakthrough, offering hope for healing and long-term remission.

#CARTtherapy #TumorVitality #CancerTreatment #NewMedicalTechnologies #MedicalAdvancement #Bloodcancer #cancersuvivor #lymphoma

11 months ago CAR-T

Two Years of Complete Remission(Lymphoma), CAR-T therapy has given her a new lease on life.

“Two Years of Complete Remission, CAR-T therapy has given her a new lease on life. She Thought the Journey Was Over”

Yun is a 78-year-old patient who achieved a continuous complete remission for two and a half years despite relapsed/refractory diffuse large B-cell lymphoma. Diagnosed in 2019, after enduring six rounds of chemotherapy, she initially achieved complete remission as confirmed by her healthcare team. Unfortunately, the period of remission was short-lived as Yun soon experienced disease relapse, and subsequent second-line treatments failed to yield positive results.

“I vividly remember when Director Wang Li encouraged me, mentioning an advanced method called Car-T, but it was quite expensive. I was hesitant, but I discussed it with my son when I got home. When my son and daughter-in-law heard about it, they insisted on treatment. My son said, ‘Mom, you’re the only mother I have in this world. As long as you’re here, our home is complete. Money can be earned again, and if the treatment isn’t successful, at least we won’t have regrets.’ I was deeply moved. At my age, I’ve already shown strength through previous treatments. I believe that wherever my health takes me is where I belong. Everyone’s support gave me a reason to stay strong again.”

In 2021, CAR-T cell therapy was approved and launched in China, and Yun underwent this treatment at Ruijin Hospital.

Dr. Wang Li, Director of Hematology at Ruijin Hospital, explained, “CAR-T cell therapy provides new treatment options for a wide range of cancer patients.”

“Before planning Yun’s CAR-T cell therapy, lymphoma experts, considering her current tumor status and medical history, anticipated potential adverse reactions during the treatment process and discussed handling protocols. Yun’s entire journey with CAR-T cell therapy was challenging. The medical team meticulously coordinated their efforts, successfully addressing adverse reactions after CAR-T treatment, ultimately averting potential risks.”

Despite lying in her hospital bed, Yun deeply appreciates the relentless dedication of her medical caregivers. “Sometimes, directors come to see me after 10 p.m., telling me they worked late but had to check on me; some arrive by my bedside as early as 7 a.m., concerned about my well-being. I continuously remind myself that I must strive, persist, and live up to the efforts made by doctors and my entire family,” said the 78-year-old Yun . “I made it through.”

#CARTCellSuccess #CancerWarrior #CompleteRemissionChronicles #FamilySupportMatters #CAR-TBreakthrough #InspiringHealthJourney #MedicalMiracles #NeverTooLateToFight #Cancerfight #Bloodcancer

#lymphoma

11 months ago CAR-T

Breakthrough Advances in CAR-T Cell Therapy Combined with TKI for Malignant Hematologic System Tumors

At this year’s ASH conference, Professor Huang He, the director of the First Affiliated Hospital of Zhejiang University School of Medicine, presented a significant study on CAR-T cell therapy for B-ALL, marking a groundbreaking stride in the treatment of malignant hematologic system tumors.

This study, targeting newly diagnosed adult Ph-positive acute lymphoblastic leukemia, investigated the combined treatment of dasatinib and CAR-T cell therapy as a frontline therapy for initial patients. The integration of CAR-T cell therapy with tyrosine kinase inhibitors (TKI) aimed to enhance treatment effectiveness.

The study revealed promising outcomes: among 18 patients, the complete molecular remission rate after CD19 CAR-T cell therapy reached 72.2%. Among these patients, subsequent treatment with CD22 CAR-T cells achieved a complete molecular remission rate of 76.9%. At a median follow-up of 13.5 months post CAR-T cell therapy, 16 patients maintained complete hematological remission, while 14 patients sustained complete molecular remission without undergoing allogeneic transplantation. Notably, no CRS (cytokine release syndrome) ≥ Grade 3 or ICANS (immune effector cell-associated neurotoxicity syndrome) occurred during CAR-T cell therapy.

Professor Huang He’s team’s groundbreaking research presented at the ASH conference signifies a leap forward in the treatment of blood-related cancers, signaling a more efficient and accessible era. These findings instill hope for refining treatment strategies and potentially making a significant impact in the field of hematologic oncology.

Beyond the groundbreaking progress in CAR-T cell therapy combined with TKI, the team showcased seven oral presentations and 26 poster exhibitions. These studies encompassed fundamental research on blood disorders, leukemia pathogenesis, acute lymphoblastic leukemia, acute myeloid leukemia, lymphoma, myeloma, hematopoietic stem cell transplantation, and cellular immunotherapy, all crucial for enhancing clinical practices.

We eagerly anticipate further groundbreaking strides by Chinese research teams in cancer treatment studies, anticipating the transformative impact of these research findings in the future.

#ASHAnnualMeeting #HematologyResearch #CARTCellTherapy #StemCellTransplantation #BloodCancer #ClinicalInnovation #OncologyAdvancements #Cancertherapy #MedicalResearch #ASH #CART #CARTTherapy #CARTCell #TKI #tyrosinekinaseinhibitors

11 months ago CAR-T

Global First: Chinese CAR-T Therapy Simultaneously Cures Tumor and Lupus Erythematosus

China make advanced medical treatment affordable

Wang Fang (pseudonym), residing in Yichang, Hubei, China, underwent a life-threatening ordeal. This patient in her forties had been suffering from systemic lupus erythematosus for over 20 years. What exacerbated her agony was the excruciating pain in her right leg since June 2019, which forced her into a wheelchair. Local hospital diagnosis revealed an aggressively invasive tumor—diffuse large B-cell lymphoma.

In mid-August 2019, Wang Fang followed a relative’s advice and sought treatment at Peking University Shenzhen Hospital (hereinafter referred to as “PKU Shenzhen Hospital”) in Shenzhen, where she was fortunate to participate in clinical trials for blood tumors. In mid-September 2019, she underwent the compound dual-target CAR-T (CD19/BCMA) cell immunotherapy.

Miraculous changes occurred a month after treatment; her lymphoma vanished entirely. Two months later, she was freed from the wheelchair and could walk independently. The nine-month follow-up, more astonishingly, revealed not only the complete disappearance of lymphoma but also the reversal of her long-standing stubborn lupus erythematosus antibodies, signifying her clinical cure from lupus.

This is the first documented instance globally where compound dual-target CAR-T cell immunotherapy cured diffuse large B-cell lymphoma and refractory lupus erythematosus—a significant breakthrough in Shenzhen’s oncology clinical research and treatment field.

This patient, originally from another region, had relied on steroids and other drugs to manage her condition for over 20 years due to systemic lupus erythematosus. However, the intensified pain in her right leg in June 2019 led to the diagnosis of an invasive tumor, rapidly deteriorating her condition and confining her to a wheelchair.

When faced with chemotherapy recommendations at the local hospital, Wang Fang declined due to the side effects she had previously experienced. Fortunately, a relative’s recommendation brought her to PKU Shenzhen Hospital. With the doctors’ dedicated assistance, Wang Fang participated in the clinical trial of CAR-T cell immunotherapy.

CAR-T cell therapy is an advanced treatment method that transforms a patient’s own T cells into CAR-T cells capable of identifying and attacking tumor cells. Since its successful treatment of the first case of acute lymphoblastic leukemia in the United States in 2012, this treatment has gradually become a groundbreaking technology in the field of tumor therapy. The Blood Department of PKU Shenzhen Hospital, as a pioneer, has completed over 30 cases of CAR-T cell therapy clinical trials, offering hope for those patients in critical conditions with ineffective traditional treatments.

Considering the uniqueness of Wang Fang’s disease, the team designed a compound dual-target CAR-T cell immunotherapy targeting both CD19 and BCMA. The success of this advanced therapy made Wang Fang the first case globally to be cured of lupus erythematosus using CAR-T cell therapy.

One month after treatment, she no longer needed wheelchair assistance; two months later, she could walk independently; and nine months later, besides the complete eradication of the tumor, the lupus erythematosus-related antibodies turned negative, leading to her clinical cure without relying on medication for her daily life.

Director Zhang Hongyu from the Blood Department of PKU Shenzhen Hospital stated that this successful case marks a significant breakthrough in CAR-T cell therapy, offering the possibility of cure to more patients. This successful clinical trial was also reported at the 61st American Society of Hematology (ASH) Annual Meeting, highlighting PKU Shenzhen Hospital’s significant contributions to the medical field.

After enduring this arduous battle, Wang Fang has regained her health and freedom. She expresses gratitude for the exceptional skills and selfless assistance of the medical team at PKU Shenzhen Hospital. Currently, for nine months, she has not taken any medication, regaining her beautiful hair and radiating vitality, looking forward to the future.

The appearance of this successful case brings hope and inspiration to the global medical community, showcasing the potential of CAR-T cell therapy in continuous exploration. The Blood Department team at PKU Shenzhen Hospital intends to continue exploring more effective and safer treatment approaches, bringing more hope for patients.

11 months ago CAR-T

Unveiling Hope: Chinese CAR-T Cell Therapy Illuminating New Paths in Liver Cancer Treatment!

2020, over 19.3 million people were diagnosed with cancer worldwide, leading to almost 10 million fatalities. In China alone, the number of new cancer patients reached a staggering 4.57 million, accounting for 23.7% globally. Liver cancer, among the most prevalent malignant tumors in China, witnessed 410,000 new cases and 380,000 deaths, making up 45.3% and 47.1% of the global total, respectively [1]. However, since the 21st century began, significant strides have been made in liver cancer treatments, particularly in medication and localized therapies. Surgical procedures are no longer the sole option for long-term survival among liver cancer patients.

Immunotherapy has emerged as one of the most promising techniques for treating liver cancer, especially with advancements in tumor molecular biology. In 2013, “Science” magazine categorized immunotherapy as the fourth major cancer treatment, following surgery, chemotherapy, and radiation therapy, with cell therapy becoming a focal point of basic and clinical research in recent years.

In May 2020, Professor Zhai Bo’s team from Shanghai Jiao Tong University School of Medicine’s Renji Hospital, in collaboration with Shanghai Sci-Tech Biotechnology’s team led by Li Zonghai, published groundbreaking preliminary clinical research data on CAR-T cell therapy targeting the GPC3 gene for hepatocellular carcinoma in the “Clinical Cancer Research” journal. This breakthrough study brought unprecedented hope for CAR-T cell therapy in liver cancer treatment.

Even more inspiring, their publication in the “Cancer Communications” journal showcased follow-up results of two late-stage liver cancer patients who achieved long-term tumor-free survival after receiving CAR-T cell combined with local therapy [2]. These findings shed new light on the treatment prospects for liver cancer patients.

However, despite the potential therapeutic effects of liver cancer CAR-T cell therapy, it faces challenges and obstacles. Liver cancer’s heterogeneity, tumor microenvironment, and the safety of cell therapy remain crucial issues to address.

Presently, revolutionary changes are underway in the treatment models and concepts for liver cancer. However, integrating CAR-T cell therapy into actual liver cancer treatment requires further scientific exploration and clinical research. Researchers emphasize that only through comprehensive utilization of CAR-T cells in conjunction with other treatment modalities can its therapeutic potential be fully realized.

Professor Zhai Bo’s team is currently conducting various fundamental and clinical studies aimed at exploring additional possibilities for CAR-T cell therapy in solid tumors. These studies include phase I clinical research on EpCAM CAR-T cell combined with ablative therapy for gastrointestinal tumors, phase II clinical research on Claudin18.2 CAR-T cell therapy for gastrointestinal tumors, studies on the mechanism and prevention of OTOT toxicity, among others. These endeavors will provide more experimental data and support for the application of CAR-T cells in the treatment of solid tumors.

In conclusion, liver cancer CAR-T cell therapy signifies a significant breakthrough in the field of liver cancer treatment, offering new hope for patients. Despite the challenges to overcome, the outlook for this therapy is promising and holds the potential to bring a blessing to more patients in the future.

[References]

Zhaibo, Lizonghai etc.

“Chimeric Antigen Receptor-Glypican-3 T-Cell Therapy for Advanced Hepatocellular Carcinoma: Results of Phase 1 Trials.” 《Clinical Cancer Research》, 2020.

“Combined local therapy and CAR-GPC3 T-cell therapy in advanced hepatocellular carcinoma: a proof-of-concept treatment strategy.” 《Cancer Communications》, 2023.

#HealthTech#CancerResearch #Immunotherapy #CARTcell #LiverCancer #MedicalBreakthrough #ClinicalTrials #ScienceNews #HealthcareInnovation #ResearchBreakthrough #MedicalScience #CancerTherapy #CancerAwareness #InnovativeMedicine #ImmunotherapyTreatment #ScienceUpdates #HealthcareTechnology #BiomedicalResearch #ClinicalInnovation #CancerTreatment #MedicalAdvancements #ImmunologyResearch #HealthcareIndustry #ProfessionalHealthcare

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Tags Archives: Chinese CAR-T

The Chinese CAR-T therapy achieves a miraculous cure for advanced liver cancer, creating wonders in the field of cellular treatment for solid tumors.