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**Breakthrough in China’s CAR-T Therapy: 13-Year-Old Girl Overcomes Lupus, Opening New Hope for a Cure**
**Breakthrough in China’s CAR-T Therapy: 13-Year-Old Girl Overcomes Lupus, Opening New Hope for a Cure**
Lupus
#LupusTreatment #HopeForLupus #lupus #AutoimmuneDisease #ChinaHealthcare #SystemicLupusErythematosus #Erythematosus #patientstory #SLE
In June 2024, 13-year-old Qingqing experienced a major turning point in her life. A year after being diagnosed with systemic lupus erythematosus (SLE), she received innovative CAR-T therapy at Shanghai Children’s Medical Center and successfully achieved disease remission. SLE, often referred to as the “incurable cancer,” is an autoimmune disease that affects millions of people worldwide, severely damaging the brain, lungs, kidneys, and blood system. Even when not in an acute flare, patients often suffer from chronic symptoms such as fatigue, rashes, pain, and fever.
Qingqing’s treatment marks a significant breakthrough in the global fight against SLE. Previously, SLE patients could only rely on lifelong medications, such as steroids and immunosuppressants, to control the disease and prevent severe complications. However, these drugs often come with side effects and long-term organ damage. Qingqing’s case has offered the world new hope. A team led by Dr. Li Benshang, chief physician of the Hematology and Oncology Department, and Dr. Yin Lei, head of the Nephrology Department, pioneered the use of CAR-T therapy in SLE treatment and initiated a clinical study. After just two months of treatment, Qingqing’s condition has fully gone into remission, and all medications were discontinued.
CAR-T therapy was originally used in cancer treatment by extracting a patient’s T cells and genetically modifying them to recognize and kill abnormal cells in the body. In the treatment of SLE, CAR-T therapy eliminates the abnormal plasma cells producing autoantibodies, effectively “resetting” the patient’s immune system and addressing the root cause of the disease.
Qingqing’s success story is not only a milestone in China’s CAR-T technology but also a major leap forward in the global treatment of autoimmune diseases like SLE. Since the first CAR-T treatment cured an SLE patient in 2021, numerous clinical trials have been conducted worldwide, and several Chinese hospitals have also achieved success. However, while early results are encouraging, further research and validation are needed to confirm the long-term safety and efficacy of the treatment.
With 20% of the global population affected by various types of autoimmune diseases, CAR-T therapy holds the potential to bring new life to millions of patients. China’s ongoing research and international collaboration in this field offer unprecedented hope for overcoming persistent diseases like SLE.
🎉🎉To assess whether the condition is suitable for CAR-T or clinic therapy, you can submit Advanced Medicine in China for preliminary evaluation!
WhatsApp: +8613717959070
(Https://wa.me/+8613717959070)
Email: doctor.huang@globecancer.com
#CAR-Ttherapy #LupusTreatment #AutoimmuneDisease #MedicalInnovation #ChinaHealthcare #Immunotherapy #CancerTreatment #HealthBreakthrough #HopeForLupus #FutureOfMedicine
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“Curing” the Untouchable Cancer – Systemic Lupus Erythematosus: Chinese Experts Take a Major Leap Forward
**”Curing” the Untouchable Cancer – Systemic Lupus Erythematosus: Chinese Experts Take a Major Leap Forward**
Lupus
#LupusTreatment #HopeForLupus #lupus #AutoimmuneDisease #ChinaHealthcare #SystemicLupusErythematosus #Erythematosus
Once hailed as a revolutionary therapy in the field of oncology, Chimeric Antigen Receptor T-cell (CAR-T) therapy is now demonstrating extraordinary potential in the treatment of Systemic Lupus Erythematosus (SLE). For this troublesome autoimmune disease that has long plagued patients and doctors alike, CAR-T therapy may be the dawn of ending this struggle.
In 2021, researchers in Germany successfully treated a 20-year-old woman with severe SLE using CAR-T therapy for the first time. While CAR-T therapy had already achieved significant success in treating hematologic malignancies, it is now opening new doors for autoimmune disease treatments. Since then, over a dozen global clinical trials have been initiated to explore CAR-T’s potential for SLE, and initial results are promising.
**How Does CAR-T Treat Lupus?**
CAR-T therapy involves extracting the patient’s T-cells, genetically modifying them to recognize and destroy harmful cells, and then reinfusing them into the body. For cancer patients, this means eliminating tumor cells; for SLE patients, it means clearing the abnormal plasma cells that produce self-antibodies, thus fundamentally curing the disease.
In China, researchers are also accelerating the application of CAR-T therapy. In June and July of 2024, two patients in Shanghai received CAR-T treatment and achieved significant results. A young girl named Qingqing and an adult woman, Ms. S, saw dramatic improvements in their symptoms and discontinued all medications related to their primary illness. Laboratory test results also showed marked improvement.
“Two months after treatment, the patients’ proteinuria disappeared, and the SLE Disease Activity Index score was 0, indicating complete remission,” said nephrologist Dr. Yin Lei. “They have returned to their normal lives.”
**Breakthroughs in Autoimmune Disease Treatment**
The success of CAR-T therapy in treating SLE is not only a boon for lupus patients but also brings new hope to millions of other autoimmune disease sufferers worldwide. Currently, about 20% of the global population is affected to varying degrees by over 100 different autoimmune diseases. The advent of CAR-T therapy could revolutionize the treatment landscape for these conditions.
Despite the promising outlook, experts remain cautious. Long-term safety and efficacy still require more research to confirm. Additionally, technical challenges such as improving the quality of T-cells after immunosuppressive therapy need to be addressed.
Nevertheless, the future looks very promising. CAR-T therapy may represent the best opportunity to overcome autoimmune diseases, including lupus.
**A Brighter Future for Lupus Patients**
Although the application of CAR-T therapy in SLE is still in its early stages, preliminary results have already brought significant hope. Future research and clinical trials will help us better understand its long-term impact and further refine the technology. For those who once faced incurable diseases, the future may no longer be so bleak.
Global pharmaceutical companies are also shifting their priorities from cancer treatment to research on autoimmune diseases. As CAR-T therapy continues to advance, more patients will benefit, bringing new hope for many.
🎉🎉To assess whether the condition is suitable for CAR-T or clinic therapy, you can submit Advanced Medicine in China for preliminary evaluation!
WhatsApp: +8613717959070
(Https://wa.me/+8613717959070)
Email: doctor.huang@globecancer.com
#CAR-Ttherapy #LupusTreatment #AutoimmuneDisease #MedicalInnovation #ChinaHealthcare #Immunotherapy #CancerTreatment #HealthBreakthrough #HopeForLupus #FutureOfMedicine
Global First: Chinese CAR-T Therapy Simultaneously Cures Tumor and Lupus Erythematosus
China make advanced medical treatment affordable
Wang Fang (pseudonym), residing in Yichang, Hubei, China, underwent a life-threatening ordeal. This patient in her forties had been suffering from systemic lupus erythematosus for over 20 years. What exacerbated her agony was the excruciating pain in her right leg since June 2019, which forced her into a wheelchair. Local hospital diagnosis revealed an aggressively invasive tumor—diffuse large B-cell lymphoma.
In mid-August 2019, Wang Fang followed a relative’s advice and sought treatment at Peking University Shenzhen Hospital (hereinafter referred to as “PKU Shenzhen Hospital”) in Shenzhen, where she was fortunate to participate in clinical trials for blood tumors. In mid-September 2019, she underwent the compound dual-target CAR-T (CD19/BCMA) cell immunotherapy.
Miraculous changes occurred a month after treatment; her lymphoma vanished entirely. Two months later, she was freed from the wheelchair and could walk independently. The nine-month follow-up, more astonishingly, revealed not only the complete disappearance of lymphoma but also the reversal of her long-standing stubborn lupus erythematosus antibodies, signifying her clinical cure from lupus.
This is the first documented instance globally where compound dual-target CAR-T cell immunotherapy cured diffuse large B-cell lymphoma and refractory lupus erythematosus—a significant breakthrough in Shenzhen’s oncology clinical research and treatment field.
This patient, originally from another region, had relied on steroids and other drugs to manage her condition for over 20 years due to systemic lupus erythematosus. However, the intensified pain in her right leg in June 2019 led to the diagnosis of an invasive tumor, rapidly deteriorating her condition and confining her to a wheelchair.
When faced with chemotherapy recommendations at the local hospital, Wang Fang declined due to the side effects she had previously experienced. Fortunately, a relative’s recommendation brought her to PKU Shenzhen Hospital. With the doctors’ dedicated assistance, Wang Fang participated in the clinical trial of CAR-T cell immunotherapy.
CAR-T cell therapy is an advanced treatment method that transforms a patient’s own T cells into CAR-T cells capable of identifying and attacking tumor cells. Since its successful treatment of the first case of acute lymphoblastic leukemia in the United States in 2012, this treatment has gradually become a groundbreaking technology in the field of tumor therapy. The Blood Department of PKU Shenzhen Hospital, as a pioneer, has completed over 30 cases of CAR-T cell therapy clinical trials, offering hope for those patients in critical conditions with ineffective traditional treatments.
Considering the uniqueness of Wang Fang’s disease, the team designed a compound dual-target CAR-T cell immunotherapy targeting both CD19 and BCMA. The success of this advanced therapy made Wang Fang the first case globally to be cured of lupus erythematosus using CAR-T cell therapy.
One month after treatment, she no longer needed wheelchair assistance; two months later, she could walk independently; and nine months later, besides the complete eradication of the tumor, the lupus erythematosus-related antibodies turned negative, leading to her clinical cure without relying on medication for her daily life.
Director Zhang Hongyu from the Blood Department of PKU Shenzhen Hospital stated that this successful case marks a significant breakthrough in CAR-T cell therapy, offering the possibility of cure to more patients. This successful clinical trial was also reported at the 61st American Society of Hematology (ASH) Annual Meeting, highlighting PKU Shenzhen Hospital’s significant contributions to the medical field.
After enduring this arduous battle, Wang Fang has regained her health and freedom. She expresses gratitude for the exceptional skills and selfless assistance of the medical team at PKU Shenzhen Hospital. Currently, for nine months, she has not taken any medication, regaining her beautiful hair and radiating vitality, looking forward to the future.
The appearance of this successful case brings hope and inspiration to the global medical community, showcasing the potential of CAR-T cell therapy in continuous exploration. The Blood Department team at PKU Shenzhen Hospital intends to continue exploring more effective and safer treatment approaches, bringing more hope for patients.