Patient Story: CAR-T Therapy Brings New Hope for Lymphoma Patients – A Case from a Chinese Hospital

**Patient Story: CAR-T Therapy Brings New Hope for Lymphoma Patients – A Case from a Chinese Hospital**

Patient Story

In the field of cancer treatment, China has achieved groundbreaking success with CAR-T cell therapy, especially in treating relapsed or refractory lymphoma. Today, we share the story of one patient whose life was transformed through this revolutionary treatment provided by a leading hospital in China.

## Patient Journey: Diagnosed with Complex Lymphoma

Mr. Li, a 59-year-old man from China with a long history of hypertension, noticed swelling in his right elbow in September 2019. As the swelling worsened over the following months, he sensed that something was seriously wrong. After evaluations at multiple hospitals, he was diagnosed with diffuse large B-cell lymphoma (DLBCL). Complicating matters, genetic testing revealed that he had TP53 and MYD88 mutations, making his case particularly challenging.

At a local hospital, Mr. Li underwent a series of standard treatments, including cyclophosphamide, prednisone, ibrutinib, and rituximab. Initially, his condition improved, but six months later, he began experiencing discomfort in his lower abdomen. Testing confirmed that his lymphoma had relapsed and spread. Multiple rounds of second-line, third-line, and even fourth-line treatments were unable to control his disease.

## Last Hope: China’s CAR-T Therapy Shows Remarkable Effect

With few options left, Mr. Li reached out to our Advanced Medicine in China team as his last hope. Our expert team took on his case, and he was promptly admitted to begin CAR-T cell therapy in China. This innovative treatment involves reprogramming the patient’s own immune cells to recognize and attack cancer cells. Chinese experts created a precise treatment plan for Mr. Li and initiated CAR-T cell infusion.

The treatment response was remarkable. Although Mr. Li experienced a brief period of fever and mild neutropenia following therapy, these symptoms resolved quickly with supportive care. He avoided severe side effects often associated with CAR-T therapy, such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). A month later, his follow-up scan revealed complete remission (CR). The Chinese CAR-T treatment not only successfully controlled his high-risk lymphoma but also spared him many of the common side effects.

## Expert Insights: A New Option for High-Risk Patients

This case demonstrates the significant effectiveness of China’s CAR-T therapy for patients with high-risk genetic mutations. Our team’s expert professor noted that patients with TP53 mutations, like Mr. Li, often respond poorly to standard first-line treatments but may achieve substantial improvement through CAR-T therapy. For high-risk patients such as Mr. Li, especially those with dual-expression and relapse within 12 months, early CAR-T treatment could yield greater benefits. CAR-T therapy in China may result in prolonged bone marrow suppression, which requires careful monitoring and supportive care based on the patient’s prior chemotherapy history and individual response.

China’s CAR-T therapy is bringing new hope for lymphoma patients around the world. It not only paves a new path in treatment options but also broadens our understanding of lymphoma treatment. By giving patients renewed hope for recovery, we look forward to this technology enabling lasting remission for even more lymphoma patients and offering a brighter future ahead.

🎉🎉To assess whether the condition is suitable for CAR-T therapy, you can submit pathology reports, treatment history, and discharge summaries to the Medical Department of <Advanced Medicine in China> for preliminary evaluation!

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Email: doctor.huang@globecancer.com

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