“Curing” the Untouchable Cancer – Systemic Lupus Erythematosus: Chinese Experts Take a Major Leap Forward

**”Curing” the Untouchable Cancer – Systemic Lupus Erythematosus: Chinese Experts Take a Major Leap Forward**

Lupus

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Once hailed as a revolutionary therapy in the field of oncology, Chimeric Antigen Receptor T-cell (CAR-T) therapy is now demonstrating extraordinary potential in the treatment of Systemic Lupus Erythematosus (SLE). For this troublesome autoimmune disease that has long plagued patients and doctors alike, CAR-T therapy may be the dawn of ending this struggle.

In 2021, researchers in Germany successfully treated a 20-year-old woman with severe SLE using CAR-T therapy for the first time. While CAR-T therapy had already achieved significant success in treating hematologic malignancies, it is now opening new doors for autoimmune disease treatments. Since then, over a dozen global clinical trials have been initiated to explore CAR-T’s potential for SLE, and initial results are promising.

**How Does CAR-T Treat Lupus?**

CAR-T therapy involves extracting the patient’s T-cells, genetically modifying them to recognize and destroy harmful cells, and then reinfusing them into the body. For cancer patients, this means eliminating tumor cells; for SLE patients, it means clearing the abnormal plasma cells that produce self-antibodies, thus fundamentally curing the disease.

In China, researchers are also accelerating the application of CAR-T therapy. In June and July of 2024, two patients in Shanghai received CAR-T treatment and achieved significant results. A young girl named Qingqing and an adult woman, Ms. S, saw dramatic improvements in their symptoms and discontinued all medications related to their primary illness. Laboratory test results also showed marked improvement.

“Two months after treatment, the patients’ proteinuria disappeared, and the SLE Disease Activity Index score was 0, indicating complete remission,” said nephrologist Dr. Yin Lei. “They have returned to their normal lives.”

**Breakthroughs in Autoimmune Disease Treatment**

The success of CAR-T therapy in treating SLE is not only a boon for lupus patients but also brings new hope to millions of other autoimmune disease sufferers worldwide. Currently, about 20% of the global population is affected to varying degrees by over 100 different autoimmune diseases. The advent of CAR-T therapy could revolutionize the treatment landscape for these conditions.

Despite the promising outlook, experts remain cautious. Long-term safety and efficacy still require more research to confirm. Additionally, technical challenges such as improving the quality of T-cells after immunosuppressive therapy need to be addressed.

Nevertheless, the future looks very promising. CAR-T therapy may represent the best opportunity to overcome autoimmune diseases, including lupus.

**A Brighter Future for Lupus Patients**

Although the application of CAR-T therapy in SLE is still in its early stages, preliminary results have already brought significant hope. Future research and clinical trials will help us better understand its long-term impact and further refine the technology. For those who once faced incurable diseases, the future may no longer be so bleak.

Global pharmaceutical companies are also shifting their priorities from cancer treatment to research on autoimmune diseases. As CAR-T therapy continues to advance, more patients will benefit, bringing new hope for many.

🎉🎉To assess whether the condition is suitable for CAR-T or clinic therapy, you can submit Advanced Medicine in China  for preliminary evaluation!

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