China’s BCMA CAR-T Therapy Offers Last Hope for Relapsed Multiple Myeloma Patients

### China’s BCMA CAR-T Therapy Offers Last Hope for Relapsed Multiple Myeloma Patients

CAR-T Therapy

Multiple myeloma remains a difficult-to-cure disease, and every year, countless patients around the world face this devastating diagnosis. While treatment options have improved in recent years, and patients’ survival times have extended, drug resistance remains a significant challenge. For patients who have experienced multiple relapses and are resistant to various treatments, the future can seem bleak. Fortunately, with the emergence of **BCMA CAR-T cell therapy**, a new ray of hope is illuminating the path for these patients.

This is the story we’re sharing today, about a 76-year-old female patient who regained control of her life through CAR-T therapy.

#### The First Encounter with the Disease

In 2020, this Chinese 76-year-old woman noticed a decline in appetite and a rapid weight loss, accompanied by persistent rib pain. She had no idea that these symptoms were early signs of multiple myeloma. After several medical tests, her Chinese doctors confirmed the diagnosis: 31% of her bone marrow cells were plasma cells, her M-protein levels reached 85.7 g/L, and calcium levels in her blood were abnormally high. Multiple bones throughout her body also showed signs of significant damage.

The diagnosis left the patient shocked and confused. Multiple myeloma wasn’t her first health challenge; she also had a history of Parkinson’s disease. However, she remained hopeful, believing that with the right treatment, her condition could be controlled. But fate had other plans.

#### The Struggle and Relapse

At the beginning of 2023, the patient’s condition relapsed rapidly. Due to a prolonged lack of regular treatment, her disease worsened, and she became resistant to many standard therapies. After extensive tests, her medical team discovered that she had a high-risk mSMART 3.0 profile, with genetic abnormalities including 1q21 amplification and a t(4;14) translocation, making her prognosis extremely poor. She was now considered a “triple-refractory” patient, resistant to three main treatment categories.

Faced with this complex and challenging situation, the Chinese doctors didn’t give up. After multiple discussions and research, they recommended a cutting-edge therapy — **BCMA CAR-T cell therapy**. This treatment involves modifying the patient’s immune cells to target and destroy cancer cells. However, to undergo this advanced therapy, the patient first needed to undergo **bridging treatment** to reduce the tumor burden in her body.

#### Bridging Treatment: A Turning Point

To prepare for CAR-T therapy, the Chinese doctors initially prescribed the **DKD regimen**, a combination therapy intended to quickly reduce the cancer cell load. However, the first treatment cycle didn’t bring significant improvement, and her free light chain levels remained high. Both the patient and her family felt disappointed, but the Chinese doctors acted quickly, switching to the **KAD regimen**, which included **liposomal doxorubicin** to further enhance the treatment’s effectiveness.

This adjustment brought immediate results. After a few weeks, her free light chain levels began to drop, and her condition showed partial remission (PR). This meant she was finally ready for CAR-T cell therapy.

#### The Miracle of CAR-T Therapy

CAR-T therapy is a breakthrough technology where the patient’s immune cells are extracted, genetically modified to recognize and destroy cancer cells, and then reintroduced into the body. These engineered cells act like precision-guided weapons, specifically targeting her cancer cells.

The patient responded positively to the treatment. Within just a few weeks, her condition was significantly controlled, with results showing a very good partial response (VGPR). For such a complex case of relapsed and refractory disease, this was a major success.

#### The Significance of the Story

This patient’s story highlights China’s latest advancements in the treatment of multiple myeloma. The use of **carfilzomib-based bridging therapy** paved the way for CAR-T therapy, successfully giving a patient with a poor prognosis a new chance at life. For those facing the dual challenges of drug resistance and relapse, **BCMA CAR-T therapy** offers not just a new treatment option, but a lifeline.

The product that has renewed hope for this 76-year-old Chinese woman is a BCMA-targeted CAR-T therapy that has already been launched in China. China is changing the fate of patients worldwide through advanced cancer treatments. Notably, in the field of CAR-T technology related to hematologic tumors and multiple myeloma, two BCMA CAR-T products have been approved in China. Especially commendable is Reindeer Bio’s independently developed fully human BCMA product, FUCASO, which has achieved an astonishing complete remission (CR) rate of 82.4%, the highest among all globally approved products. An increasing number of foreign multiple myeloma patients are now seeking treatment in China to access better therapies at more affordable prices. As China continues to develop cutting-edge medical therapies, aggressive treatments like CAR-T undoubtedly provide new hope for the future of multiple myeloma treatment.

Follow us for more stories of medical innovation and to witness how miracles of life are born in China!

To assess whether the condition is suitable for CAR-T therapy, you can submit pathology reports, treatment history, and discharge summaries to the Medical Department of <Advanced Medicine in China> for preliminary evaluation!

WhatsApp: +8613717959070

Https://wa.me/+8613717959070

Email: doctor.huang@globecancer.com

#MultipleMyeloma #CancerTreatment #CAR_TTherapy #BCMACAR_T #CancerSurvivor #Immunotherapy #ChinaMedicalInnovation #CancerResearch #CancerHope #MedicalBreakthrough #MyelomaAwareness #AdvancedCancerCare #RelapsedMyeloma #LifeSavingTreatment #PatientSuccessStory #CancerCare #GlobalHealth #CAR_TSuccess #Oncology #CancerSupport

#ChineseMedical #ChinaHealthcare #MedicalCareInChina #HealthcareInChina ·  #USMedical #USHealthcare  #HealthcareInUSA #AmericanMedical #MedicalCareInUSA #USAHealth #AmericanHealthcare

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1 week ago Hematological Neoplasms

Blood Cancer – Diagnosis and Treatment Tips

Blood Cancer – Diagnosis and Treatment Tips

#leukemia #multiplemyeloma #lymphoma

Blood Cancer

Blood cancer, encompassing types such as leukemia, lymphoma, and multiple myeloma, represents a significant health challenge in regions like Southeast Asia and India. These hematologic malignancies arise from blood-forming cells and can impact the bone marrow, blood, and various organs. The increasing prevalence of these diseases is concerning, yet advancements in diagnosis and treatment provide hope for patients.

## Understanding Hematologic Malignancies

Hematologic malignancies include a variety of cancers such as:

– **Leukemia**: Cancer of the bone marrow that leads to the overproduction of abnormal white blood cells.

– **Lymphoma**: Affects the lymphatic system and includes #Hodgkin and #nonHodgkinlymphoma.

– **Multiple Myeloma**: Cancer that forms in plasma cells, affecting the production of antibodies.

The causes of these conditions are multifactorial, involving genetic factors, immune dysfunction, exposure to environmental toxins, and lifestyle choices. For instance, a diet high in processed foods, sedentary behavior, and high stress levels can contribute to an increased risk of developing these cancers.

## The Rising Incidence of Blood Cancer

The incidence of blood cancers is on the rise globally, particularly in countries with aging populations. In Southeast Asia and India, there has been a noticeable increase in cases of leukemia and lymphoma, necessitating better awareness and improved healthcare infrastructure.

## Diagnosis: Early Detection is Key

Early diagnosis is crucial for successful treatment outcomes. Patients experiencing symptoms such as unexplained fatigue, frequent infections, easy bruising, or swollen lymph nodes should seek medical advice promptly. Healthcare providers may utilize blood tests, bone marrow biopsies, and imaging studies to diagnose these conditions accurately.

## Treatment Advances: A Diverse Approach

Recent years have seen significant advancements in the treatment of hematologic malignancies, offering patients more options than ever before:

1. **Combination Chemotherapy**: Despite potential side effects, combination chemotherapy remains a cornerstone treatment. New regimens are being developed that combine traditional cytotoxic drugs with targeted therapies and immunotherapies to enhance efficacy and reduce toxicity.

2. **Targeted Therapies**: Drugs that specifically target cancer cell mutations or characteristics are revolutionizing treatment. For example, *Gleevec*, the first targeted therapy, has dramatically improved survival rates for chronic myeloid leukemia (#CML).

3. **Monoclonal Antibodies**: Often dubbed “biological missiles,” these treatments target specific proteins on cancer cells, allowing for more precise treatment with fewer side effects.

4. **Hematopoietic Stem Cell Transplantation**: This procedure remains one of the most effective treatments for certain types of blood cancer, especially when other treatments fail.

5. **Immunotherapy**: This approach harnesses the body’s immune system to fight cancer. Techniques like CAR-T cell therapy, which modifies a patient’s T cells to attack cancer cells, have shown promising results in treating various hematologic malignancies. China is at the forefront of CAR-T cell therapy research and application, particularly in treating hematologic malignancies. CAR-T therapy involves extracting a patient’s T cells, modifying them to specifically recognize and attack cancer cells. Clinical research and applications in China have shown remarkable effectiveness in treating leukemia, lymphomas, and multiple myeloma. Some studies indicate that patients receiving CAR-T treatment experience significantly higher long-term survival rates and lower recurrence rates. Furthermore, China has made significant progress in the standardization of CAR-T therapy, personalized treatment plans, and the development of technological platforms, enabling more patients to benefit from this innovative treatment.

## Hope for the Future

Countries like India and those in Southeast Asia are rapidly advancing in the field of blood cancer treatment. Collaborative efforts among healthcare professionals, research institutions, and patient advocacy groups are crucial for improving access to cutting-edge therapies. The development of treatment guidelines tailored to the regional context can ensure that patients receive the best possible care.

### Conclusion

Hematologic malignancies are challenging but treatable diseases. Through early diagnosis and the application of innovative therapies, patients can achieve significant improvements in their health and quality of life. As research continues to evolve, the prospect of long-term survival and even cures for blood cancers is becoming increasingly attainable. Empowering patients with knowledge and access to modern treatments is essential to fighting blood cancer effectively in #SoutheastAsia and #India.

To assess whether the condition is suitable for clinic therapy, you can submit Advanced Medicine in China for preliminary evaluation!

WhatsApp: +8613717959070

Https://wa.me/+8613717959070

Email: doctor.huang@globecancer.com

#HematologicMalignancies #LeukemiaAwareness #LymphomaResearch #MultipleMyeloma #BloodCancer #CancerResearch #CAR_Therapy #StemCellTransplant #Immunotherapy #TargetedTherapy #MonoclonalAntibodies #CancerTreatment #MedicalAdvancements #CancerSurvivor #HealthcareInnovation #ALL #AML

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2 weeks ago Myeloma

**China’s CAR-T Therapy Brings Complete Remission for Primary Refractory Multiple Myeloma Patient**

**China’s CAR-T Therapy Brings Complete Remission for Primary Refractory Multiple Myeloma Patient**

Multiple Myeloma

#MultipleMyeloma #CARTtherapy #BloodCancer #CompleteRemission #CART

 

    Multiple Myeloma (MM) is a malignant blood disorder characterized by abnormal proliferation of plasma cells, which causes damage to vital organs. Patients with high-risk cytogenetic abnormalities like 17p deletion, t(4;14) translocation, and t(14;16) translocation face an even worse prognosis. While new drugs like proteasome inhibitors and autologous stem cell transplantation have improved MM treatment outcomes, relapsed/refractory multiple myeloma (RRMM) continues to be a challenge due to its aggressive nature and tendency to relapse. Despite the use of traditional therapies, many patients either fail to respond or cannot tolerate further treatment due to underlying health issues.

    CAR-T cell therapy, a novel immunotherapy that re-engineers the patient’s own T cells to attack cancer cells, has shown remarkable results in RRMM patients. It offers an alternative for patients who have poor tolerance to conventional treatments, presenting a safer and more effective option. In particular, Equecabtagene Autoleucel, a CAR-T therapy targeting the BCMA antigen on myeloma cells, has demonstrated success in treating patients unresponsive to frontline therapies.

### Case Study: High-Risk MM Patient Achieves Complete Remission

A 45-year-old male patient diagnosed with high-risk multiple myeloma in June 2023 sought further treatment at our hospital after failing to respond to chemotherapy. He had a history of coronary artery disease, diabetes, hypertension, and kidney artery stenosis, making traditional therapies less effective and risky.

    Upon evaluation, the patient’s tests indicated κ-type M protein and abnormal free light chains (FLC-κ of 2410.5mg/L). Imaging scans revealed extensive bone damage caused by multiple myeloma. Genetic testing showed high-risk markers including 17p deletion and 1q21 amplification, further complicating his prognosis.

    Given his high-risk status and poor response to standard treatments, the medical team decided to proceed with CAR-T cell therapy using Equecabtagene Autoleucel. After a smooth cell collection and lymphodepletion process, the patient received CAR-T infusion on November 15, 2023.

### Treatment Outcome and Safety

Eight days after infusion, the patient developed a mild fever, indicating cytokine release syndrome (CRS), which was effectively managed with symptomatic treatment. Despite mild kidney dysfunction and temporary blood cell reductions, no severe side effects or neurotoxicities occurred. By day 42, the patient developed a lung infection, which was treated with antibiotics, leading to a full recovery.

    At the one-month follow-up, flow cytometry showed no minimal residual disease (MRD), confirming the patient had achieved complete remission (CR) with MRD negativity. This outcome was particularly significant considering the patient’s failure to respond to previous treatments.

### A Promising Future for High-Risk MM Patients

This case highlights the potential of CAR-T cell therapy, particularly Equecabtagene Autoleucel, in achieving deep remission for high-risk multiple myeloma patients who fail to respond to conventional therapies. With ongoing advancements in biomedical technology and immunotherapy, CAR-T treatments offer hope for RRMM patients, providing longer disease-free survival and improved quality of life.

🎉🎉To assess whether the condition is suitable for clinic therapy, you can submit Advanced Medicine in China for preliminary evaluation!

WhatsApp: +8613717959070

Https://wa.me/+8613717959070

Email: doctor.huang@globecancer.com

#ChinaMedicalAdvances #InnovativeTreatments #Immunotherapy #EquecabtageneAutoleucel #CancerResearch

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2 weeks ago CAR-T

The significance of the 11 CD19 and BCMA CAR-T therapies currently approvedin China and the U.S. forpatients with hematologic malignancies.

The significance of the 11 CD19 and BCMA CAR-T therapies currently approvedin China and the U.S. forpatients with hematologic malignancies.

目前中美上市的11款CD19和BCMA CAR-T对血液瘤患者的意义

Expert：

**Jing Pan**

**Associate Chief Physician**

**Department of Pediatric Hematology, Beijing Gaobo Hospital**

**Professional Memberships:**

– Member, Pediatric Oncology Professional Committee of the Chinese Anti-Cancer Association

– Youth Committee Member, Hematologic Oncology Professional Committee of the Chinese Anti-Cancer Association

– Youth Committee Member, Clinical Application Professional Committee of the Chinese Medical Biotechnology Association

**Expertise:**

Dr. Pan currently manages an 80-bed pediatric hematology unit and has extensive experience in pediatric hematology, particularly in CAR-T cell immunotherapy, with nearly 10 years of experience in the field. She is dedicated to stratified CAR-T treatment, optimizing the management of complications during CAR-T therapy, and establishing an efficacy monitoring system post-treatment. Dr. Pan and her team have accumulated one of the largest single-center case collections globally, particularly in the areas of sequential CAR-T therapy for improving long-term outcomes in B-ALL and in exploring autologous and allogeneic CD5, CD7 CAR-T therapy for T-ALL/LBL.

Her related clinical research on CD7 CAR-T, CD19 CAR-T, CD22 CAR-T, and CD19-22 sequential CAR-T has been published in leading international journals such as *Lancet Oncology*, *JCO*, *Blood*, *JHO*, and *Leukemia*. Additionally, she has frequently presented the latest advancements in her team’s immunotherapy research at both domestic and international conferences, including ASCO, ASH, EHA, and JSH.

潘 静

副主任医师

北京高博医院 小儿血液科

中国抗癌协会小儿肿瘤专业委员会专业委员

中国抗癌协会血液肿瘤专业委员会青年委员

中国医药生物技术协会医药生物技术临床应用专业委员会青年委员

擅长:

目前独立管理床位数80张的儿童血液病区。从事儿童血液科临床工作多年，特别是在儿童CAR-T细胞免疫治疗方面积累了近10年的经验。致力于CAR-T的分层治疗，优化CAR-T治疗过程中的并发症处理，建立CAR-T治疗后的疗效监控体系。尤其是其带领团队在序贯CAR-T提高B-ALL远期预后，T-ALL/LBL的自体、异体CD5、CD7CAR-T治疗探索方面目前积累了全球较大的单中心病例数。相关的CD7CAR-T临床研究、CD19CAR-T临床研究、CD22CAR-T临床研究、CD19-22序贯CAR-T研究等，发表在国际血液病权威杂志期刊Lancet on-cology、JC0、Blood、JHO和Leukemia。并多次在国内外学术会议(美国临床肿瘤大会ASCO、美国血液年会ASH、欧洲血液年会EHA、日本血液年会JSH)汇报团队免疫治疗的最新进展。

To assess whether the condition is suitable for clinic therapy, you can submit Advanced Medicine in China for preliminary evaluation!

WhatsApp: +8613717959070

Https://wa.me/+8613717959070

Email: doctor.huang@globecancer.com

#cart #carttherapy #CAR_T #leukemia #lymphoma #cancer #tumor #bloodcancer

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3 weeks ago Myeloma

BCMA CAR-T Therapy Paves New Path for Treating High-Risk Multiple Myeloma

**BCMA CAR-T Therapy Paves New Path for Treating High-Risk Multiple Myeloma**

Multiple Myeloma

Multiple Myeloma (MM) is a malignant tumor originating from plasma cells, known for its complex biology and treatment resistance, presenting significant challenges to patients’ survival. For high-risk MM, especially in cases of relapse and refractory disease after multiple lines of therapy, treatment options become critically important. Recently, a team led by Professor Qian from a Chinese Hospital successfully treated a high-risk relapsed/refractory MM (RRMM) patient using BCMA CAR-T cell therapy, offering new hope for difficult-to-treat cases.

**Patient Overview**

The patient, a 56-year-old woman, initially sought treatment for persistent anemia and back pain. Baseline examinations revealed significant abnormalities, including a hemoglobin level of 67g/L, thrombocytopenia, and abnormal bone marrow findings. She was diagnosed with IgG-kappa type MM at stage ISS III/R-ISS III, with cytogenetic abnormalities and high-risk factors such as t(14;16) and 1q21 amplification. The disease rapidly progressed despite multiple lines of therapy, including VRd and DVD regimens, with external manifestations of extramedullary disease (EMD), indicating a poor prognosis.

**Treatment Journey**

The patient initially underwent VRd induction therapy, followed by DVD treatment when the disease progressed. Despite efforts, she developed multiple extramedullary lesions, leading to the use of the Dara+DECP regimen and autologous stem cell transplantation (ASCT). While these treatments provided partial remission, the disease relapsed within months, with extramedullary involvement further complicating the prognosis.

Given the poor prognosis and lack of effective treatments for EMD in MM, the decision was made to pursue BCMA CAR-T cell therapy, specifically with **Equecabtagene Autoleucel**, China’s first CAR-T product for treating MM. This therapy has demonstrated an impressive overall response rate (ORR) of 100% in patients with extramedullary disease, with a complete remission (CR) rate of 78.6%.

**CAR-T Therapy and Outcomes**

Following preconditioning with FC regimen, the patient underwent BCMA CAR-T therapy. After CAR-T infusion, the patient experienced mild cytokine release syndrome (CRS), which was successfully managed with supportive care. Over the course of three months, significant clinical improvements were observed. PET-CT scans showed no residual disease, and bone marrow biopsies were negative for clonal plasma cells. The patient achieved stringent complete remission (sCR).

Eight months after CAR-T therapy, follow-up results continue to show no evidence of disease, with the patient maintaining CR. This case highlights the long-lasting anti-tumor effects of Equecabtagene Autoleucel, a fully human BCMA CAR-T product, which offers low immunogenicity and sustained CAR-T cell persistence in vivo.

**Implications for Future Treatment**

This success story offers new hope for patients with high-risk and refractory MM, especially those with extramedullary involvement. It also provides valuable clinical insights into the use of BCMA CAR-T therapy as a promising treatment strategy. The case demonstrates that for patients with high-risk MM, comprehensive risk assessment considering genetic characteristics, treatment responses, and future treatment plans is essential for personalized care.

In conclusion, the application of Equecabtagene Autoleucel CAR-T therapy represents a significant breakthrough in the treatment of high-risk, refractory MM, particularly in cases involving extramedullary disease. This innovative approach not only extends survival but also enhances the quality of life for patients who have exhausted other treatment options, marking a new chapter in the fight against multiple myeloma.

🎉🎉To assess whether the condition is suitable for clinic therapy, you can submit Advanced Medicine in China for preliminary evaluation!

WhatsApp: +8613717959070

Https://wa.me/+8613717959070

Email: doctor.huang@globecancer.com

#MultipleMyeloma #CAR_Therapy #BCMA #CancerTreatment #InnovativeMedicine #Immunotherapy #ExtramedullaryDisease #RelapsedMM #ChinaHealthcare #GlobalHealth

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3 weeks ago Myeloma

Uncovering the Hidden Threat: How Serum Protein Electrophoresis Helps Diagnose Multiple Myeloma

**Uncovering the Hidden Threat: How Serum Protein Electrophoresis Helps Diagnose Multiple Myeloma**

Serum Protein Electrophoresis

#MultipleMyeloma #BloodCancer #SerumProteinElectrophoresis #MM #Mprotein #monoclonalprotein #SPE

As we age, it’s common to experience certain health issues—unexplained anemia, bone pain, fractures, nausea, or abnormal urine changes. Many may dismiss these symptoms as a result of aging, poor diet, or even mild illness. However, such seemingly unrelated signs could indicate a more serious condition: **Multiple Myeloma (MM)**.

**What is Multiple Myeloma (MM)?**

Multiple Myeloma is a type of blood cancer that originates in the bone marrow, where abnormal plasma cells multiply uncontrollably. These malignant cells produce large amounts of a protein called **M-protein** (monoclonal protein), leading to damage in various organs such as the kidneys and bones. The condition is complex, with different patients exhibiting diverse symptoms, often making it challenging to diagnose early. Key factors contributing to MM include genetic mutations and chromosomal changes, alongside abnormalities in the bone marrow microenvironment.

**Why is Early Detection Crucial?**

Over the past few decades, MM cases have steadily increased, particularly among older adults. Delayed diagnosis can result in severe complications, impacting the patient’s quality of life. Due to its subtle onset and wide range of symptoms, many MM patients may see multiple specialists without receiving the correct diagnosis. This makes raising awareness of MM screening critical—early detection can significantly improve survival and quality of life.

One of the most effective tools for early diagnosis is **Serum Protein Electrophoresis (SPE)**—a simple yet powerful lab test that can detect the presence of abnormal proteins, such as M-protein, in the blood.

**How Serum Protein Electrophoresis (SPE) Works**

SPE works by separating the proteins in your blood serum based on their size and electrical charge. Imagine it like children sliding down a playground slide, each going at different speeds depending on their size and shape. Similarly, proteins in the blood move at varying speeds in an electric field. This separation allows us to visualize distinct “protein bands” that represent different proteins like albumin and globulins. For MM patients, the presence of a sharp spike (M-protein) in the **gamma globulin region** serves as a telltale sign of the disease.

This method not only helps in identifying MM but also plays a key role in monitoring disease progression and assessing the effectiveness of treatment. By measuring the quantity of M-protein, doctors can gauge the severity of the disease and tailor therapies accordingly.

**Beyond Multiple Myeloma: Other Uses of SPE**

While SPE is essential for diagnosing MM, it is also a useful tool for identifying other conditions, including **liver diseases**, **kidney disorders**, and **chronic infections**. For example, in patients with liver cirrhosis, SPE often shows an increase in **beta and gamma globulin**, creating a distinctive pattern called a **beta-gamma bridge**. Similarly, kidney disease patients typically exhibit reduced albumin levels. By analyzing these patterns, doctors gain deeper insights into the underlying health issues.

**Other Diagnostic Tools for MM**

In addition to SPE, there are several other lab tests and imaging techniques that can help detect MM. These include **complete blood counts (CBC)**, **kidney function tests**, **calcium levels**, and imaging such as **X-rays** or **MRIs**. Research has shown that combining various tests, such as hemoglobin, globulin, HDL cholesterol, and uric acid, enhances the early detection of MM.

**A Complex Disease with Varied Outcomes**

Though multiple myeloma remains incurable, treatments can significantly extend survival, especially when caught early. If you or someone you know is experiencing unexplained symptoms like persistent anemia, unusual bone pain, or kidney issues, it’s essential to seek evaluation by a hematologist. Timely diagnosis and treatment are critical to improving both prognosis and quality of life.

**Stay informed, stay vigilant, and prioritize early screening** to protect yourself from the silent threat of multiple myeloma.

To assess whether the condition is suitable for clinic therapy, you can submit Advanced Medicine in China for preliminary evaluation!

WhatsApp: +8613717959070 (Https://wa.me/+8613717959070)

Email: doctor.huang@globecancer.com

#MultipleMyeloma #BloodCancer #CancerAwareness #EarlyDiagnosis #SerumProteinElectrophoresis #HealthTips #MMResearch #CancerScreening #BloodTests #HealthyAging #MedicalBreakthrough

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1 month ago Hematological Neoplasms

Hematologic Tumors – Detection: Unveiling the Mysteries of the Disease

**Hematologic Tumors** – Detection:

Unveiling the Mysteries of the Disease

#Hematologic #BloodCancer #CancerDetection #Leukemia #Lymphoma #MultipleMyeloma

Hematologic tumors are a group of malignant diseases caused by the abnormal proliferation of blood-forming cells, affecting the bone marrow, blood, and various organs and tissues throughout the body. Common types of hematologic tumors include leukemia, myelodysplastic syndromes, lymphoma, multiple myeloma, and myeloproliferative neoplasms.

### Causes of Hematologic Tumors

The development of hematologic tumors is highly complex. Key factors include genetic mutations, immune system abnormalities, radiation exposure, contact with harmful chemicals, viral infections, and hereditary factors. Additionally, unhealthy lifestyle habits, prolonged psychological stress, and poor environmental conditions can increase the risk of these diseases.

In recent years, due to global population aging and modern lifestyle changes, the incidence of hematologic tumors has been on the rise. In China, leukemia and lymphoma rank among the top malignant tumors in terms of incidence and mortality. Therefore, early detection and accurate diagnosis of hematologic tumors are crucial for improving patient outcomes.

### Detection Methods for Hematologic Tumors

Since early symptoms of hematologic tumors are often subtle, many patients are diagnosed in the late stages of the disease. Thus, early detection is essential. The medical field has developed a variety of advanced and precise diagnostic methods to detect and confirm hematologic tumors.

#### 1. **Blood Tests**

A complete blood count (CBC) is a fundamental tool for detecting hematologic tumors. By analyzing the quantity and morphology of red blood cells, white blood cells, and platelets, physicians can preliminarily identify abnormalities. For example, leukemia patients often exhibit abnormal increases or decreases in white blood cells, along with immature cells in the bloodstream.

#### 2. **Bone Marrow Biopsy**

Bone marrow biopsy is a key diagnostic method for hematologic tumors. By analyzing the hematopoietic cells from a bone marrow sample, physicians can determine the presence of abnormal or malignant cell proliferation. This procedure not only confirms the type of hematologic tumor but also helps assess disease progression and treatment efficacy.

#### 3. **Flow Cytometry**

Flow cytometry is an efficient method for detecting hematologic tumors. It rapidly analyzes characteristic markers on the surface of cells, helping doctors identify and quantify abnormal cells. It plays an essential role in diagnosing diseases such as leukemia and lymphoma.

#### 4. **Genetic Testing**

Genetic mutations are a critical factor in many hematologic tumors. Genetic testing can reveal the mutation profile within a patient’s cells, enabling doctors to better understand the underlying cause of the disease and formulate personalized treatment plans. With advancements in molecular biology, genetic testing has become a cornerstone of precision medicine.

#### 5. **Imaging Tests**

For certain aggressive hematologic tumors, imaging tests like CT, PET-CT, and MRI help doctors assess the extent and spread of the disease. These techniques are particularly valuable in staging and evaluating the treatment response of lymphomas.

### Conclusion

The detection of hematologic tumors has become increasingly accurate, greatly improving early diagnosis rates and treatment outcomes. By effectively utilizing blood tests, bone marrow biopsies, flow cytometry, genetic testing, and imaging, patients can receive earlier diagnoses and more tailored treatment plans. With continuous advances in medical technology, the cure rates for hematologic tumors are expected to rise, bringing hope for better health to more patients.

To assess whether the condition is suitable for CAR-T or clinic therapy, you can submit Advanced Medicine in China for preliminary evaluation!

WhatsApp:+8613717959070

（Https://wa.me/+8613717959070）

Email: doctor.huang@globecancer.com

#HematologicCancer #BloodCancer #CancerDetection #LeukemiaAwareness #LymphomaAwareness #MultipleMyeloma #CancerDiagnosis #GeneticTesting #EarlyDetection #FlowCytometry #BoneMarrowBiopsy #CancerResearch #PrecisionMedicine #CancerTreatment #Immunotherapy #Oncology #CancerAwareness #HealthInnovation #MedicalAdvancements #CancerCare

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1 month ago Myeloma

**Treatment for Multiple Myeloma: China’s BCMA×CD3 Bispecific Antibody Proposed for Breakthrough Therapy Designation**

**Treatment for Multiple Myeloma: China’s BCMA×CD3 Bispecific Antibody Proposed for Breakthrough Therapy Designation**

Multiple Myeloma

#MultipleMyeloma #BCMAxCD3 #BispecificAntibody #Immunotherapy #GR1803 #NMPA #RRMM

Recently, GR1803, an injectable solution developed by Genrix Bio, has been proposed for the “Breakthrough Therapy Designation” by the Center for Drug Evaluation (CDE) under China’s National Medical Products Administration (NMPA). This innovative drug targets relapsed and refractory multiple myeloma (RRMM), especially for patients who have undergone at least three lines of treatment, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody.

GR1803 is a novel bispecific antibody that simultaneously binds to BCMA and CD3 antigens. Its unique design allows for the effective activation of T-cells to attack tumor cells while minimizing non-specific T-cell activation, reducing potential side effects. In its Phase I clinical trial for RRMM, GR1803 demonstrated an overall objective response rate (ORR) of 85%, with an ORR of 100% in patients with extramedullary plasmacytoma (EMM).

The clinical performance of this product is remarkable, as evidenced by data presented at the 2024 European Hematology Association (EHA) annual meeting. As of January 2024, 40 trial participants have been enrolled, with an ORR of 85%. Notably, in the 180 ug/kg dose group, the median follow-up duration was 15 weeks, and 96% of the patients achieved a significant response.

What’s particularly noteworthy is the rapid response time; patients showed signs of improvement within a median of just 3 weeks. This suggests that GR1803 not only provides effective disease control in the short term but also continues to enhance patients’ conditions as treatment progresses.

The results from Genrix Bio’s research highlight that GR1803 offers new hope for RRMM patients, particularly for those who are unresponsive to conventional therapies. Its high response rate and favorable safety profile suggest that this drug could play a critical role in future cancer treatments.

The development of such groundbreaking drugs and the advancement of breakthrough therapies reflect China’s growing innovation in the global fight against cancer, offering new treatment options for patients worldwide.

🎉🎉To assess whether the condition is suitable for CAR-T or clinic therapy, you can submit Advanced Medicine in China  for preliminary evaluation!

WhatsApp: +8613717959070  

Https://wa.me/+8613717959070

Email: doctor.huang@globecancer.com

#MultipleMyeloma #CancerTreatment #BreakthroughTherapy #Immunotherapy #BiotechInnovation #GenrixBio #BCMAxCD3 #CancerResearch #OncologyNews #PharmaInnovation

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2 months ago CAR-T

China’s first BCMA CAR-T therapy successfully treats an overseas patient with advanced relapsed multiple myeloma

China’s first BCMA CAR-T therapy successfully treats an overseas patient with advanced relapsed myeloma.

🎉🎉To assess whether the condition is suitable for CAR-T or clinic therapy, you can submit Advanced Medicine in China for preliminary evaluation!

WhatsApp:+8613717959070

Https://wa.me/+8613717959070

Email: doctor.huang@globecancer.com

#MultipleMyeloma #CAR-T #CancerTreatment #MedicalBreakthrough #Oncology #HealthcareInnovation #BCMACART

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2 months ago Myeloma , CAR-T

China’s Fully Human BCMA CAR-T Therapy: Bringing New Hope for High-Risk Relapsed/Refractory Multiple Myeloma

China’s Fully Human BCMA CAR-T Therapy: Bringing New Hope for High-Risk Relapsed/Refractory Multiple Myeloma

Mutiple Myeloma

Multiple Myeloma (MM) is a complex and aggressive cancer originating from plasma cells, posing significant treatment challenges due to its resistance to therapy. For patients with high-risk MM, especially those who experience relapse after multiple lines of treatment, finding an effective therapy is critical. Recently, Chinese medical team successfully treated a case of high-risk relapsed/refractory MM (RRMM) using fully human BCMA CAR-T cell therapy, offering new hope for such difficult cases.

 

**Case Overview**

The patient, a 56-year-old woman, presented with anemia during a routine check-up and was later diagnosed with MM. Despite undergoing several treatment regimens, including VRd (bortezomib, lenalidomide, dexamethasone) and Dara-DECP followed by autologous stem cell transplantation (ASCT), the disease continued to progress, with extramedullary disease (EMD) manifestations complicating the case.

**Challenges and Treatment Journey**

After initial treatments failed to achieve long-term remission, the patient’s condition worsened, with new lesions detected in the pancreas and multiple subcutaneous nodules indicating possible metastasis. Given the aggressive nature of the disease and the presence of EMD, which is associated with a poor prognosis, the medical team opted for a BCMA-targeted CAR-T cell therapy using Iquarense (Ikaros CAR-T), the first CAR-T product approved for MM treatment in China.

**CAR-T Therapy and Results**

Following pre-conditioning with a fludarabine-cyclophosphamide (FC) regimen, the patient received the BCMA CAR-T therapy. The treatment was well-tolerated, with only mild cytokine release syndrome (CRS) observed. Remarkably, within three months post-treatment, PET-CT scans showed no signs of active disease, and the patient achieved a complete response (CR), which has been sustained for eight months.

**Significance and Future Implications**

This case highlights the potential of BCMA CAR-T therapy as a powerful option for patients with high-risk, relapsed/refractory MM, particularly those with EMD. The successful outcome not only provides new hope for patients facing similar challenges but also contributes valuable insights for future treatment strategies. Iquarense, with its low immunogenicity and prolonged persistence in the body, represents a promising advance in the fight against this formidable disease.

For patients with high-risk MM, it is crucial to consider genetic factors, treatment response, and overall disease dynamics when selecting a therapeutic approach. As this case demonstrates, BCMA CAR-T therapy offers a viable path forward, particularly for those with limited options due to disease progression or EMD.

To assess whether the condition is suitable for CAR-T or clinic therapy, you can submit Advanced Medicine in China for preliminary evaluation!

WhatsApp: +8613717959070

 (Http://wa.me/+8613717959070)

Email: doctor.huang@globecancer.com

#BloodCancerTreatment #CAR_TCellTherapy #CancerBreakthrough #Immunotherapy #BCMACART #MedicalAdvancements #CancerSurvivorship #ChinaMedicalInnovation #HopeForCancerPatients

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