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🎉 #PNAS Breaking News: Revolutionary CAR-T Cell Therapy Successfully Treats Autoimmune Disease in China! 🎉
🎉 #PNAS Breaking News: Revolutionary CAR-T Cell Therapy Successfully Treats Autoimmune Disease in China! 🎉
PNAS
In a groundbreaking development, Chinese medical experts have achieved a milestone in the treatment of autoimmune diseases using CAR-T cell therapy.
🩺 A New Hope for Autoimmune Diseases
Autoimmune-mediated necrotizing myopathy (#IMNM) poses a significant challenge in clinical management due to its severe symptoms and limited efficacy of traditional pharmacological approaches. However, a ray of hope emerges with the application of Chimeric Antigen Receptor (CAR) T-cell therapy targeting B cell maturation antigen (#BCMA).
🔬 The Breakthrough Study
Published in the prestigious #journal PNAS, the study titled “Single-cell analysis of refractory anti-SRP necrotizing myopathy treated with anti-BCMA CAR-T cell therapy” by the medical team at Huazhong University of Science and Technology sheds light on a remarkable case. A patient with anti-signal recognition particle (SRP) IMNM exhibited significant improvement in clinical symptoms and sustained reduction in pathogenic autoantibodies after receiving BCMA-targeted CAR-T cell therapy for over 18 months.
🧬 Understanding the Mechanisms
Through longitudinal single-cell RNA sequencing and analysis of T cell receptors and B cell receptors, researchers elucidated the normalization of the immune microenvironment post-CAR-T cell infusion. The expansion of CD8+ CAR-T cells, coupled with dynamic phenotypic transitions in both CD4+ and CD8+ CAR-T cells, was observed, indicating a promising avenue for the treatment of autoimmune diseases.
🔍 Implications for the Future
This study not only highlights the efficacy of CAR-T cell therapy in refractory IMNM but also underscores the importance of understanding the molecular characteristics of CAR-T cells in autoimmune diseases. Further research is warranted to enhance the efficiency and durability of CAR-T cell therapy for autoimmune conditions.
🌟 Hope for Patients Worldwide
With this groundbreaking achievement, there is renewed hope for millions of individuals battling autoimmune diseases globally. Stay tuned for more updates as we continue to unlock the potential of innovative therapies in medical science!
🎉🎉To assess whether the condition is suitable for CAR-T or clinic therapy, you can submit Advanced Medicine in China for preliminary evaluation!
Email: doctor.huang@globecancer.com,
WhatsApp: +8613717959070
#CAR_TTherapy #AutoimmuneDisease #MedicalBreakthrough #Science #Innovation #PNAS #cart #cartcell #BCMA #IMNM #chineseresearch #medicalscience
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World’s First! Chinese Tongji Hospital Successfully Treats Immune-Mediated Necrotizing Myopathy with CAR-T Cells!
🎉🔬✨ World’s First! Chinese Tongji Hospital Successfully Treats Immune-Mediated Necrotizing Myopathy with CAR-T Cells! ✨🔬🎉
PNAS
🌟A groundbreaking achievement in medicine! Immune-Mediated Necrotizing Myopathy
Professor Wang Wei’s team from Tongji Hospital, affiliated with Huazhong University of Science and Technology, has brought unprecedented hope to patients with immune-mediated necrotizing myopathy. 🌟
📅 On January 30th, their research was published in the prestigious journal “Proceedings of the National Academy of Sciences” (PNAS). They utilized CAR-T cells targeting mature B cell antigen (BCMA) for the first time, achieving significant clinical efficacy in treating immune-mediated necrotizing myopathy. This research opens new avenues for treating this condition, marking a historic breakthrough in medicine.
ℹ️ CAR-T cell therapy
is a gene-editing cellular treatment method. Patient’s own T cells are extracted, genetically modified in vitro to possess targeted killing capabilities. These modified CAR-T cells are then reintroduced into the patient’s body to selectively eliminate target cells, bringing about dramatic changes in the disease’s progression.
Tongji
👨⚕️ Patient Mr. Deng is a successful case of CAR-T cell therapy. Diagnosed with immune-mediated necrotizing myopathy seven and a half years ago, his condition worsened over time, leaving him bedridden. After receiving CAR-T treatment, his health significantly improved, he successfully entered graduate school for medical studies, achieved full recovery, discontinued all immunosuppressive drugs, and now lives medication-free. This is a remarkable victory! 💪
🌈 What’s even more surprising is that several patients treated with CAR-T cells experienced the regrowth of new B cells approximately one year post-treatment. These new B cells exhibit a completely different phenotype, and pathogenic antibodies in the patients’ bodies completely disappear, achieving a joyful “immune reshaping.”
🌍 This breakthrough research brings hope to autoimmune disease patients worldwide.
Professor Wang Wei’s team’s efforts have paved the way for new treatment approaches, offering a fresh start for patients once deemed untreatable. We look forward to the global adoption of this treatment method, benefiting more patients worldwide. Let’s cheer for this remarkable achievement together! 👏
In addition to lung cancer, we are currently urgently recruiting patients with B-cell lymphoma, T-cell lymphoma, T-cell leukemia (T-ALL), acute lymphoblastic leukemia, myeloma, and other types of cancer!
You can send electronic copies or photos of genetic testing reports and diagnostic reports to the email address:
doctor.huang@globecancer.com,
or click on the
WhatsApp+8613717959070.
The Medical Department will contact you as soon as they receive the reports.🌟
#CARTCellTherapy #ImmuneMediated #NecrotizingMyopathy #MedicalBreakthrough #TongjiHospital #ScientificResearch #MedicalRevolution #HealthHope #myopathy