CAR-T Therapy in China: Relma-cel Offers Deep and Lasting Remission for Patients with Relapsed/Refractory Mantle Cell Lymphoma (MCL)

CAR-T Therapy in China: Relma-cel Offers Deep and Lasting Remission for Patients with Relapsed/Refractory Mantle Cell Lymphoma (MCL)

MCL

#MantleCellLymphoma #MCL  #Lymphoma #RRMCL  #RelmaCel #CART #Non-HodgkinLymphoma #NHL

In the global cancer treatment landscape, the advancements in CAR-T cell therapy are remarkable, particularly in the treatment of relapsed and refractory Mantle Cell Lymphoma (MCL). China’s CAR-T therapy, Relma-cel, has emerged as a new beacon of hope for patients, delivering deep and lasting remission for those who have undergone multiple lines of treatment.

Mantle Cell Lymphoma: A Complex and Challenging Disease

Mantle Cell Lymphoma (MCL) is a subtype of Non-Hodgkin Lymphoma (NHL) originating from B cells, accounting for 6% to 8% of all NHL cases. The disease typically affects older adults, and most patients are diagnosed at an advanced stage with poor prognostic factors. Despite the availability of various treatments, including Bruton’s Tyrosine Kinase inhibitors (BTKi), MCL remains difficult to cure, and patients often face recurrence or progression of the disease.

Relma-cel: A New Hope for Relapsed/Refractory MCL

In China, Relma-cel, a novel CAR-T cell therapy, was approved by the National Medical Products Administration (NMPA) in August 2024 for the treatment of adult patients with relapsed or refractory MCL who have failed multiple lines of therapy. This therapy offers a groundbreaking treatment option for MCL patients.

A Case Study: Deep Remission Achieved with CAR-T Therapy

A 51-year-old male MCL patient, after multiple treatment failures, eventually achieved complete remission through the CAR-T therapy Relma-cel. Diagnosed in 2014, the patient underwent R-CHOP chemotherapy, Rituximab-targeted therapy, as well as BTKi and PI3K inhibitor treatments. However, the disease continued to relapse with poor prognosis. Finally, in 2022, the patient achieved deep and lasting remission through CAR-T therapy. After CAR-T cell infusion, the patient reached complete remission within just one month and remained in remission for 22 months of follow-up.

Expert Commentary: The Future of CAR-T Therapy

Professor Li Ping from Tongji Hospital, Tongji University, highlighted that CAR-T cell therapy has broken through the limitations of traditional treatments for relapsed/refractory MCL, offering new hope for high-risk patients. For those who cannot benefit from conventional treatments, the introduction of CAR-T therapy is crucial, especially when applied early in the frontline treatment stage to maximize its efficacy.

Based on the latest clinical research data, Relma-cel has shown encouraging complete remission rates (67.8%) and objective response rates (81.36%) in treating relapsed/refractory MCL patients. These findings further underscore the importance of CAR-T cell therapy in patients who have failed BTKi treatment, positioning it as a potential first-choice treatment for these patients.

Globally, CAR-T therapy has become a standard treatment for relapsed/refractory MCL, particularly in third-line treatment settings. For patients with poor prognostic factors, CAR-T therapy may be key to overcoming the limitations of traditional treatments and extending survival.

Conclusion

As CAR-T cell therapy continues to evolve, more patients with relapsed/refractory MCL will have the opportunity to benefit from it. The clinical application of Relma-cel not only brings deep and lasting remission to patients but also sets a new example for the development of CAR-T therapy worldwide. With early intervention and precise treatment strategies, CAR-T therapy has the potential to create a brighter future for MCL patients.

🎉🎉To assess whether the condition is suitable for CAR-T or clinic therapy, you can submit Advanced Medicine in China  for preliminary evaluation!

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